Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.72 |
| ▸ | MEN1 | O00255 | 8/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.72 |
| ▸ | MAPT | P10636 | 6/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.72 |
| ▸ | HPGD | P15428 | 4/20 | 0.72 |
| ▸ | HTT | P42858 | 3/20 | 0.72 |
| ▸ | NPC1 | O15118 | 1/20 | 0.72 |
| ▸ | RAB9A | P51151 | 1/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 4/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31723137 | 1.00 | KDM4E (0.72) | KDM4EMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL31723182 | 0.90 | MAPT (0.85) | KDM4EMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL20918213 | 0.90 | MAPT (0.85) | KDM4EMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL31723158 | 0.90 | MAPT (0.68) | KDM4EMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL28431175 | 0.90 | MAPT (0.68) | KDM4EMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL6527669 | 0.86 | ALDH1A1 (0.69) | KDM4EMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL31723150 | 0.85 | MAPT (0.70) | KDM4EMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL20919306 | 0.85 | MAPT (0.59) | KDM4EMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL31723166 | 0.85 | MAPT (0.70) | KDM4EMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL31723140 | 0.85 | MAPT (0.59) | KDM4EMEN1KMT2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111315730-A | Composition for preventing or treating tumor necrosis factor-related diseases comprising novel derivative as active ingredient and method for inhibiting tumor necrosis factor activity using the same | 艾伊莱布 | 2020-06-19 | — | — | CN | claimed |
| CN-111315730-A | Composition for preventing or treating tumor necrosis factor-related diseases comprising novel derivative as active ingredient and method for inhibiting tumor necrosis factor activity using the same | 艾伊莱布 | 2020-06-19 | — | — | CN | disclosed |