Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Rabeprazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 2/20 | 0.58 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.58 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.58 |
| ▸ | OPRD1 known ✓ | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 known ✓ | P41145 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.58 |
| ▸ | WDR5 | P61964 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | ENGASE | Q8NFI3 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | DDAH1 | O94760 | 2/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.58 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.58 |
| ▸ | NPY1R | P25929 | 2/20 | 0.58 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.58 |
| ▸ | HTR3A | P46098 | 2/20 | 0.58 |
| ▸ | FASN | P49327 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rabeprazole SCHEMBL2998947 | 0.96 | KMT2A (0.60) | KMT2AALDH1A1CYP2C9WDR5LMNA | |
| Rabeprazole SCHEMBL140495 | 0.96 | KMT2A (0.60) | KMT2AALDH1A1CYP2C9WDR5LMNA | |
| Dexrabeprazole SCHEMBL22189141 | 0.96 | KMT2A (0.60) | KMT2AALDH1A1CYP2C9WDR5LMNA | |
| Rabeprazole SCHEMBL491358 | 0.96 | KMT2A (0.60) | KMT2AALDH1A1CYP2C9WDR5LMNA | |
| Rabeprazole SCHEMBL2998946 | 0.96 | KMT2A (0.60) | KMT2AALDH1A1CYP2C9WDR5LMNA | |
| Rabeprazole SCHEMBL27964348 | 0.95 | KMT2A (0.59) | KMT2AALDH1A1CYP2C9WDR5LMNA | |
| Rabeprazole SCHEMBL23337 | 0.95 | KMT2A (0.61) | KMT2AALDH1A1CYP2C9WDR5LMNA | |
| Dexrabeprazole SCHEMBL30945135 | 0.95 | KMT2A (0.61) | KMT2AALDH1A1CYP2C9WDR5LMNA | |
| Dexrabeprazole SCHEMBL30019061 | 0.95 | KMT2A (0.61) | KMT2AALDH1A1CYP2C9WDR5LMNA | |
| Dexrabeprazole SCHEMBL4946138 | 0.95 | KMT2A (0.61) | KMT2AALDH1A1CYP2C9WDR5LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111417730-A | Diagnostic method | 托雷莫治疗股份公司 | 2020-07-14 | — | — | CN | claimed |
| CN-111417730-A | Diagnostic method | 托雷莫治疗股份公司 | 2020-07-14 | — | — | CN | disclosed |