Rabeprazole

Rabeprazole

SCHEMBL491358

COCCCOc1ccnc(C[S+]([O-])c2nc3ccccc3[nH]2)c1C.[NaH]

nearest known ligand 0.60

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 0.60
CYP2C9 P11712 4/20 0.60
WDR5 P61964 4/20 0.60
LMNA P02545 4/20 0.60
ENGASE Q8NFI3 3/20 0.60
ALDH1A1 P00352 3/20 0.60
MAPT P10636 3/20 0.60
DDAH1 O94760 2/20 0.60
ADORA3 P0DMS8 2/20 0.60
HPGD P15428 2/20 0.60
TBXA2R P21731 2/20 0.60
NPY1R P25929 2/20 0.60
ADORA1 P30542 2/20 0.60
OPRM1 P35372 2/20 0.60
HTR3A P46098 2/20 0.60
FASN P49327 2/20 0.60
SARM1 Q6SZW1 2/20 0.60
ABCG2 Q9UNQ0 2/20 0.60
PDE4D Q08499 2/20 0.60
HTR1A P08908 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Rabeprazole SCHEMBL2998947 1.00 KMT2A (0.60) KMT2ACYP2C9WDR5LMNAENGASE
Rabeprazole SCHEMBL2998946 1.00 KMT2A (0.60) KMT2ACYP2C9WDR5LMNAENGASE
Dexrabeprazole SCHEMBL22189141 1.00 KMT2A (0.60) KMT2ACYP2C9WDR5LMNAENGASE
Rabeprazole SCHEMBL140495 1.00 KMT2A (0.60) KMT2ACYP2C9WDR5LMNAENGASE
Rabeprazole SCHEMBL27964348 0.99 KMT2A (0.59) KMT2ACYP2C9WDR5LMNAENGASE
Dexrabeprazole SCHEMBL30945135 0.99 KMT2A (0.61) KMT2ACYP2C9WDR5LMNAENGASE
Dexrabeprazole SCHEMBL30019061 0.99 KMT2A (0.61) KMT2ACYP2C9WDR5LMNAENGASE
Dexrabeprazole SCHEMBL4946138 0.99 KMT2A (0.61) KMT2ACYP2C9WDR5LMNAENGASE
Rabeprazole SCHEMBL29374701 0.99 KMT2A (0.61) KMT2ACYP2C9WDR5LMNAENGASE
Rabeprazole SCHEMBL23336 0.99 KMT2A (0.61) KMT2ACYP2C9WDR5LMNAENGASE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 678 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120131579-A Enteric coated tablet containing rabeprazole sodium and application thereof 郑州大学第一附属医院 2025-06-13 CN claimed
CN-118903309-A Application of compound PIANZAIHUANG buccal tablet in preparing medicine for preventing and/or treating laryngopharyngeal reflux disease 漳州片仔癀药业股份有限公司 2024-11-08 CN claimed
CN-118311216-B Rapid determination method for dissolution rate of sodium rabeprazole enteric-coated tablets 湖南明瑞制药股份有限公司 2024-09-13 CN claimed
CN-118311216-A Rapid determination method for dissolution rate of sodium rabeprazole enteric-coated tablets 湖南明瑞制药股份有限公司 2024-07-09 CN claimed
CN-118258939-A Method for detecting levo-rabeprazole and dextro-rabeprazole in human plasma 烟台大学 2024-06-28 CN claimed
CN-116236580-B Application of old medicines such as auranofin and the like and compositions thereof in resisting single positive strand RNA viruses 中国科学院上海药物研究所 2024-05-24 CN claimed
CN-118010878-A Determination method and application of impurities in sodium rabeprazole enteric-coated preparation 丽珠集团丽珠制药厂 2024-05-10 CN claimed
CN-117949559-A Method for testing related substances in sodium rabeprazole enteric-coated tablets 湖南九典制药股份有限公司 2024-04-30 CN claimed
CN-114609268-B Detection method for related substances in sodium rabeprazole bulk drug 南京海纳医药科技股份有限公司 2024-04-16 CN claimed
CN-115252610-B Use of proton pump inhibitors against coronaviruses 上海科技大学 2024-03-26 CN claimed
US-20060178406-A1 Process for production of sulfoxide derivatives or salts thereof in the amorphous state EISAI R&D MANAGEMENT CO., LTD. (JP) 2006-08-10 US claimed
CN-1729974-A Soft capsule of sodium rabeprazole and its preparation process BEIJING LANBEIWANG MEDICINE TE (CN) 2006-02-08 CN claimed
EP-1607395-A1 PROCESS FOR PRODUCTION OF SULFOXIDE DERIVATIVES OR SALTS THEREOF IN THE AMORPHOUS STATE Eisai Co., Ltd. (JP) 2005-12-21 EP claimed
US-20050234103-A1 Crystalline forms of rabeprazole sodium DR. REDDY'S LABORATORIES, INC. 2005-10-20 US claimed
EP-1487820-A1 CRYSTALLINE FORMS OF RABEPRAZOLE SODIUM Dr. Reddy's Laboratories Ltd. (IN) 2004-12-22 EP claimed
EP-1000943-B1 Sulfoxide compounds and acetone complexes, and a process for producing the same EISAI CO LTD (JP) 2004-02-18 EP claimed
WO-2003082858-A1 CRYSTALLINE FORMS OF RABEPRAZOLE SODIUM DR. REDDY'S LABORATORIES LIMITED (IN) 2003-10-09 WO claimed
US-6545024-B1 Complexing acetone with sulfoxides such as Rabeprazole, Lansoprazole, Omeprazole or Pantoprazole; inhibitors of gastric acid secretion and anti-ulcer agents or as intermediates for production of medicines EISAI CO., LTD. (JP) 2003-04-08 US claimed
US-6180652-B1 ANTIULCER, ANTISECRETORY AGENTS EISAI CO., LTD. (JP) 2001-01-30 US claimed
EP-1000943-A1 Sulfoxide compounds and acetone complexes, and a process for producing the same Eisai Co., Ltd. (JP) 2000-05-17 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050234103-A1 Crystalline forms of rabeprazole sodium RAB7A, RABL3, RAB27A KMT2A 3014/4885CYP2C9 79/4885WDR5 1450/4885
US-20060178406-A1 Process for production of sulfoxide derivatives or salts thereof in the amorphous state MSRB3, SCLY, AS3MT KMT2A 804/4885CYP2C9 1086/4885WDR5 1826/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.