Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | HTR7 | P34969 | 5/20 | 0.50 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.50 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2845082 | 0.98 | CYP1A2 (0.56) | CYP1A2MAPK1SMN1; SMN2SIGMAR1HTR7 | |
| SCHEMBL4912945 | 0.92 | HTR7 (0.54) | CYP1A2MAPK1SMN1; SMN2SIGMAR1HTR7 | |
| SCHEMBL13660052 | 0.87 | PAOX (0.62) | CYP1A2SIGMAR1HTR7PAOXCHRNA7 | |
| SCHEMBL13660053 | 0.84 | SIGMAR1 (0.50) | CYP1A2MAPK1SMN1; SMN2SIGMAR1HTR7 | |
| SCHEMBL24694352 | 0.83 | CYP1A2 (0.52) | CYP1A2MAPK1SMN1; SMN2SIGMAR1HTR7 | |
| SCHEMBL9149589 | 0.81 | CYP1A2 (0.80) | CYP1A2MAPK1SMN1; SMN2HTR7PAOX | |
| SCHEMBL9152244 | 0.81 | CYP1A2 (0.80) | CYP1A2MAPK1SMN1; SMN2HTR7PAOX | |
| SCHEMBL11851576 | 0.81 | CYP1A2 (0.80) | CYP1A2MAPK1SMN1; SMN2HTR7PAOX | |
| SCHEMBL9151071 | 0.81 | CYP1A2 (0.80) | CYP1A2MAPK1SMN1; SMN2HTR7PAOX | |
| SCHEMBL9150946 | 0.81 | CYP1A2 (0.80) | CYP1A2MAPK1SMN1; SMN2HTR7PAOX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100130474-A1 | ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR INHIBITORS | WYETH (US) | 2010-05-27 | — | — | US | disclosed |
| US-20100029606-A1 | MODULATORS OF ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTORS AND THERAPEUTIC USES THEREOF | WYETH (US) | 2010-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029606-A1 | MODULATORS OF ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTORS AND THERAPEUTIC USES THEREOF | CHRNA7, CHRNA2, CHRNA6 | CYP1A2 1261/4885MAPK1 1781/4885SMN1; SMN2 2002/4885 |
| US-20100130474-A1 | ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR INHIBITORS | CHRNA7, CHRNA6, CHRNA2 | CYP1A2 2584/4885MAPK1 1513/4885SMN1; SMN2 1693/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.