Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28432216 | 0.76 | HTT (0.58) | HTTLMNAMAPTRXFP1POLB | |
| SCHEMBL28425965 | 0.75 | ALDH1A1 (0.46) | HTTMAPTALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL12622649 | 0.70 | POLB (0.52) | LMNAMAPTRXFP1POLBKMT2A | |
| SCHEMBL29167150 | 0.69 | AXL (0.68) | HTTLMNAMAPTPOLBKMT2A | |
| SCHEMBL8875381 | 0.69 | MAPT (0.58) | HTTLMNAMAPTKMT2AALDH1A1 | |
| SCHEMBL19241147 | 0.68 | HTT (0.69) | HTTLMNAMAPTRXFP1KMT2A | |
| SCHEMBL28436992 | 0.68 | HTT (0.47) | HTTLMNAMAPTKMT2AALDH1A1 | |
| SCHEMBL8097877 | 0.67 | HTT (0.47) | HTTLMNAMAPTPOLBKMT2A | |
| SCHEMBL8106915 | 0.67 | HTT (0.50) | HTTLMNAMAPTPOLBKMT2A | |
| SCHEMBL28437295 | 0.66 | ALDH1A1 (0.38) | HTTLMNAMAPTALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111057023-A | 1-aryl-tetrazole-5-nitrile and 2-aryl-tetrazole-5-nitrile and preparation method thereof | 天津大学 | 2020-04-24 | — | — | CN | disclosed |