Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2727664 | 1.00 | SMN1; SMN2 (0.41) | SMN1; SMN2CYP2C19NPC1RAB9AHTR2C | |
| SCHEMBL30694003 | 0.83 | PSEN1 (0.40) | — | |
| SCHEMBL29185150 | 0.83 | PSEN1 (0.40) | — | |
| SCHEMBL29560191 | 0.81 | SMN1; SMN2 (0.45) | SMN1; SMN2CYP2C19NPC1RAB9A | |
| SCHEMBL30693995 | 0.81 | AGTR2 (0.40) | SMN1; SMN2NPC1RAB9AHTR2C | |
| SCHEMBL3742158 | 0.80 | DUT (0.34) | — | |
| SCHEMBL211191 | 0.80 | DUT (0.34) | — | |
| SCHEMBL6475389 | 0.80 | PREP (0.49) | NPSR1 | |
| SCHEMBL6475398 | 0.80 | PREP (0.49) | NPSR1 | |
| SCHEMBL6484219 | 0.80 | PREP (0.49) | NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2195328-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Incorporated (US) | 2010-06-16 | — | — | EP | disclosed |
| WO-2009023193-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2009-02-19 | — | — | WO | disclosed |