Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 5/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.79 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.79 |
| ▸ | LMNA | P02545 | 2/20 | 0.79 |
| ▸ | PKM | P14618 | 2/20 | 0.71 |
| ▸ | NPBWR1 | P48145 | 4/20 | 0.65 |
| ▸ | RIPK1 | Q13546 | 4/20 | 0.64 |
| ▸ | HPGD | P15428 | 3/20 | 0.64 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.60 |
| ▸ | CDK9 | P50750 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | MMP2 | P08253 | 1/20 | 0.56 |
| ▸ | MMP9 | P14780 | 1/20 | 0.56 |
| ▸ | MMP8 | P22894 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7608611 | 0.92 | KDM4E (0.85) | KDM4EMAPTALDH1A1KCNJ1LMNA | |
| SCHEMBL1250581 | 0.91 | KDM4E (0.82) | KDM4EMAPTALDH1A1KCNJ1LMNA | |
| SCHEMBL9721028 | 0.89 | KDM4E (0.81) | KDM4EMAPTALDH1A1KCNJ1LMNA | |
| SCHEMBL9720952 | 0.89 | KDM4E (0.81) | KDM4EMAPTALDH1A1KCNJ1LMNA | |
| SCHEMBL783687 | 0.89 | KDM4E (0.81) | KDM4EMAPTALDH1A1KCNJ1LMNA | |
| SCHEMBL8601352 | 0.89 | KDM4E (0.80) | KDM4EMAPTALDH1A1KCNJ1LMNA | |
| SCHEMBL6753969 | 0.88 | KDM4E (0.79) | KDM4EMAPTALDH1A1KCNJ1LMNA | |
| SCHEMBL9642133 | 0.88 | MAPT (1.00) | KDM4EMAPTALDH1A1KCNJ1LMNA | |
| SCHEMBL7033535 | 0.87 | MAPT (0.91) | KDM4EMAPTALDH1A1KCNJ1LMNA | |
| SCHEMBL18459774 | 0.84 | MAPT (0.76) | KDM4EMAPTALDH1A1KCNJ1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5763473-A | Use of 2-substituted benzimidazole as smooth muscle cell proliferation inhibitors | AMERICAN HOME PROCUCTS CORPORATION (US) | 1998-06-09 | — | — | US | disclosed |
| US-5654436-A | INHIBITORS OF SMOOTH MUSCLE CELL PROLIFERATION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-08-05 | — | — | US | disclosed |