Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 7/20 | 0.56 |
| ▸ | JAK3 | P52333 | 5/20 | 0.56 |
| ▸ | JAK1 | P23458 | 2/20 | 0.56 |
| ▸ | TYK2 | P29597 | 1/20 | 0.56 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.54 |
| ▸ | LGMN | Q99538 | 1/20 | 0.53 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | SYK | P43405 | 2/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.48 |
| ▸ | CDK4 | P11802 | 1/20 | 0.48 |
| ▸ | CCND1 | P24385 | 1/20 | 0.48 |
| ▸ | CCND2 | P30279 | 1/20 | 0.48 |
| ▸ | CCND3 | P30281 | 1/20 | 0.48 |
| ▸ | STAT6 | P42226 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29670005 | 0.88 | JAK2 (0.60) | JAK2JAK3JAK1TYK2PTK2 | |
| SCHEMBL28451613 | 0.87 | JAK2 (0.59) | JAK2JAK3JAK1TYK2SYK | |
| SCHEMBL28435371 | 0.85 | LGMN (0.49) | PTK2LGMNDGAT1GAAMAPT | |
| SCHEMBL28435369 | 0.81 | — | — | |
| SCHEMBL24426200 | 0.81 | JAK2 (0.62) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL28672349 | 0.80 | JAK2 (0.51) | JAK2JAK3HDAC1HDAC6SYK | |
| SCHEMBL28441100 | 0.79 | JAK2 (0.61) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL16453360 | 0.78 | TNK2 (0.79) | JAK2TYK2PTK2 | |
| SCHEMBL16453415 | 0.78 | TNK2 (0.79) | JAK2TYK2PTK2 | |
| SCHEMBL16453382 | 0.78 | TNK2 (0.79) | JAK2TYK2PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113891881-A | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2022-01-04 | — | — | CN | disclosed |
| CN-111423384-B | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2021-10-15 | — | — | CN | disclosed |
| CN-111423384-A | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2020-07-17 | — | — | CN | disclosed |