Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 7/20 | 0.59 |
| ▸ | JAK3 | P52333 | 5/20 | 0.59 |
| ▸ | JAK1 | P23458 | 3/20 | 0.59 |
| ▸ | TYK2 | P29597 | 3/20 | 0.59 |
| ▸ | SYK | P43405 | 6/20 | 0.58 |
| ▸ | IGF1R | P08069 | 1/20 | 0.52 |
| ▸ | STAT6 | P42226 | 1/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.52 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.50 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.50 |
| ▸ | CDK1 | P06493 | 1/20 | 0.50 |
| ▸ | CDK4 | P11802 | 1/20 | 0.50 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.50 |
| ▸ | CCND1 | P24385 | 1/20 | 0.50 |
| ▸ | CCND2 | P30279 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29670005 | 0.91 | JAK2 (0.60) | JAK2JAK3JAK1TYK2SYK | |
| SCHEMBL28435366 | 0.87 | JAK2 (0.56) | JAK2JAK3JAK1TYK2SYK | |
| SCHEMBL28441100 | 0.86 | JAK2 (0.61) | JAK2JAK3JAK1TYK2SYK | |
| SCHEMBL24426200 | 0.85 | JAK2 (0.62) | JAK2JAK3JAK1TYK2FLT3 | |
| SCHEMBL28451619 | 0.84 | MAPK9 (0.48) | JAK2JAK3JAK1TYK2MAPK8 | |
| SCHEMBL28451616 | 0.80 | — | — | |
| SCHEMBL24426206 | 0.79 | JAK2 (0.55) | JAK2JAK3JAK1TYK2SYK | |
| SCHEMBL22860801 | 0.77 | JAK2 (0.82) | JAK2JAK3JAK1TYK2FLT3 | |
| SCHEMBL29670019 | 0.77 | JAK2 (0.57) | JAK2JAK3JAK1TYK2SYK | |
| SCHEMBL28679840 | 0.77 | JAK2 (0.57) | JAK2JAK3JAK1TYK2SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111423384-A | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2020-07-17 | — | — | CN | claimed |
| CN-111423384-B | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2021-10-15 | — | — | CN | disclosed |
| CN-111423384-A | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2020-07-17 | — | — | CN | disclosed |