Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LGMN | Q99538 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28451619 | 0.88 | MAPK9 (0.48) | LMNAALDH1A1SMN1; SMN2TSHRMCOLN3 | |
| SCHEMBL28435366 | 0.85 | JAK2 (0.56) | LGMNMAPTPTK2SMN1; SMN2GAA | |
| SCHEMBL28440872 | 0.81 | JAK2 (0.48) | MAPTLMNAALDH1A1SMN1; SMN2HTT | |
| SCHEMBL28445178 | 0.81 | ALDH1A1 (0.41) | LMNAALDH1A1SMN1; SMN2PLA2G1BGAA | |
| SCHEMBL28441103 | 0.80 | MAPK9 (0.47) | LMNAALDH1A1SMN1; SMN2TSHRMCOLN3 | |
| SCHEMBL28443652 | 0.74 | JAK2 (0.64) | MAPTLMNAALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL28435369 | 0.73 | — | — | |
| SCHEMBL28442722 | 0.73 | FGFR4 (0.71) | — | |
| SCHEMBL29670005 | 0.72 | JAK2 (0.60) | PTK2 | |
| SCHEMBL22860796 | 0.72 | MAPT (0.60) | MAPTLMNAALDH1A1SMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111423384-B | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2021-10-15 | — | — | CN | disclosed |
| CN-111423384-A | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2020-07-17 | — | — | CN | disclosed |