Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.57 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | STK17B | O94768 | 1/20 | 0.37 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2838329 | 0.79 | BCHE (0.48) | EPHX1OPRM1OPRD1OPRK1OGFRL1 | |
| SCHEMBL5113769 | 0.76 | EPHX1 (0.73) | EPHX1OPRM1OPRD1OPRK1OGFRL1 | |
| SCHEMBL2846431 | 0.76 | STK17B (0.45) | EPHX1GAATDP1MEN1KMT2A | |
| SCHEMBL32660220 | 0.74 | EPHX1 (0.53) | EPHX1GAANPSR1POLB | |
| SCHEMBL32660206 | 0.74 | EPHX1 (0.53) | EPHX1GAANPSR1POLB | |
| SCHEMBL5416045 | 0.74 | EPHX1 (0.70) | EPHX1GAATDP1MEN1KMT2A | |
| SCHEMBL14506128 | 0.73 | EPHX1 (1.00) | EPHX1GAAEPHX2 | |
| SCHEMBL2632886 | 0.72 | TDP1 (0.45) | EPHX1GAATDP1MEN1KMT2A | |
| SCHEMBL2842705 | 0.72 | STK17B (0.47) | GAATDP1MEN1KMT2ABCHE | |
| SCHEMBL19263939 | 0.71 | EPHX1 (0.66) | EPHX1GAATDP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2145879-B1 | Pyrazine derivatives, methods of use, and methods for preparing same | MEDIBEACON LLC (US) | 2015-07-29 | — | — | EP | disclosed |
| EP-2145879-B1 | Pyrazine derivatives, methods of use, and methods for preparing same | MEDIBEACON LLC (US) | 2015-07-29 | — | — | EP | disclosed |
| US-8481734-B2 | Pyrazine derivatives and uses thereof, including in medical imaging and visualization applications | MEDIBEACON DEVELOPMENT LLC (US) | 2013-07-09 | — | — | US | disclosed |
| US-20100021382-A1 | Pyrazine Derivatives and Uses Thereof | MALLINCKRODT INC. (US) | 2010-01-28 | — | — | US | disclosed |
| EP-2145879-A1 | Pyrazine derivatives, methods of use, and methods for preparing same | Mallinckrodt Inc. (US) | 2010-01-20 | — | — | EP | disclosed |
| US-20100010223-A1 | Pyrazine derivatives, Methods of use, and methods for preparing same | MALLINCKRODT INC. (US) | 2010-01-14 | — | — | US | disclosed |
| US-20100010223-A1 | Pyrazine derivatives, Methods of use, and methods for preparing same | MALLINCKRODT INC. (US) | 2010-01-14 | — | — | US | disclosed |
| EP-2143716-A1 | Pyrazine derivatives, methods of use, and methods for preparing same | Mallinckrodt Inc. (US) | 2010-01-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100010223-A1 | Pyrazine derivatives, Methods of use, and methods for preparing same | DPYD, DHPS, DHX15 | EPHX1 866/4885OPRM1 2593/4885OPRD1 3358/4885 |
| US-20100021382-A1 | Pyrazine Derivatives and Uses Thereof | DPYD, PRDX5, NOX5 | EPHX1 1983/4885OPRM1 2100/4885OPRD1 1935/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.