Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 3/20 | 0.73 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5416045 | 0.98 | EPHX1 (0.70) | EPHX1GAATDP1BTKMEN1 | |
| SCHEMBL19263939 | 0.95 | EPHX1 (0.66) | EPHX1GAATDP1BTKMEN1 | |
| SCHEMBL5619433 | 0.92 | EPHX1 (0.60) | EPHX1GAATDP1BTKMEN1 | |
| SCHEMBL24435431 | 0.91 | EPHX1 (0.65) | EPHX1GAATDP1MEN1KMT2A | |
| SCHEMBL12894206 | 0.91 | EPHX1 (0.65) | EPHX1GAATDP1MEN1KMT2A | |
| SCHEMBL18257482 | 0.89 | EPHX1 (0.60) | EPHX1GAATDP1BTKMEN1 | |
| SCHEMBL13627401 | 0.89 | EPHX1 (0.62) | EPHX1GAATDP1BTKMEN1 | |
| SCHEMBL26043679 | 0.89 | EPHX1 (0.62) | EPHX1GAATDP1BTKMEN1 | |
| SCHEMBL26158775 | 0.88 | EPHX1 (0.62) | EPHX1GAATDP1BTKMEN1 | |
| SCHEMBL22096232 | 0.88 | EPHX1 (0.59) | EPHX1GAATDP1BTKMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11142543-B2 | Antidepressant compound and preparation method and application thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2021-10-12 | — | — | US | disclosed |
| US-20200385418-A1 | ANTIDEPRESSANT COMPOUND AND PREPARATION METHOD AND APPLICATION THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2020-12-10 | — | — | US | disclosed |
| EP-3564253-A1 | ANTIDEPRESSANT COMPOUND AND PREPARATION METHOD AND APPLICATION THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2019-11-06 | — | — | EP | disclosed |
| US-7414067-B2 | Ophthalmic compositions for treating ocular hypertension | MERCK & CO. INC. (US) | 2008-08-19 | — | — | US | disclosed |
| EP-1610776-A4 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | MERCK & CO INC (US) | 2007-03-28 | — | — | EP | disclosed |
| US-20060069256-A1 | Ophthalmic compositions for treating ocular hypertension | EVOTEC OAI (GB) | 2006-03-30 | — | — | US | disclosed |
| EP-1610776-A2 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | Merck & Co. Inc. (US) | 2006-01-04 | — | — | EP | disclosed |
| WO-2004087051-A2 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | MERCK & CO., INC. (US) | 2004-10-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060069256-A1 | Ophthalmic compositions for treating ocular hypertension | KCNN1, KCNN3, KCNN2 | EPHX1 1491/4885GAA 2150/4885TDP1 2978/4885 |
| US-11142543-B2 | Antidepressant compound and preparation method and application thereof | TPH1, BDNF, CRH | EPHX1 1551/4885GAA 1014/4885TDP1 2801/4885 |
| US-20200385418-A1 | ANTIDEPRESSANT COMPOUND AND PREPARATION METHOD AND APPLICATION THEREOF | TPH1, BDNF, CRH | EPHX1 1551/4885GAA 1014/4885TDP1 2801/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.