SCHEMBL28435846

SCHEMBL28435846

CC(C)(C)NC(=O)c1cnn(CC(=CF)CNC(=O)OC(C)(C)C)c1

nearest known ligand 0.38

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
AOC3 Q16853 4/20 0.38
MAOB P27338 1/20 0.38
SCD O00767 1/20 0.35
HDAC3 O15379 1/20 0.34
HDAC8 Q9BY41 1/20 0.34
NCOR2 Q9Y618 1/20 0.34
BRD4 O60885 1/20 0.34
KLKB1 P03952 1/20 0.33
NAMPT P43490 1/20 0.31
LMNA P02545 3/20 0.31
HPGD P15428 1/20 0.31
KDM4E B2RXH2 1/20 0.31
ACHE P22303 1/20 0.31
AR P10275 3/20 0.31
ALDH1A1 P00352 1/20 0.31
MAPT P10636 1/20 0.31
SERPINE1 P05121 1/20 0.31
ACACB O00763 1/20 0.31
ACACA Q13085 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29441559 1.00 AOC3 (0.38) AOC3MAOBSCDHDAC3HDAC8
SCHEMBL28433237 0.91 SCD (0.34) SCDHDAC3HDAC8NCOR2KLKB1
SCHEMBL22207024 0.90 LMNA (0.35) SCDHDAC3HDAC8NCOR2KLKB1
SCHEMBL22207026 0.90 LMNA (0.35) SCDHDAC3HDAC8NCOR2KLKB1
SCHEMBL23907150 0.88 L3MBTL1 (0.41) SCDHDAC3HDAC8NCOR2BRD4
SCHEMBL23907153 0.88 L3MBTL1 (0.41) SCDHDAC3HDAC8NCOR2BRD4
SCHEMBL28427420 0.87 HDAC3 (0.33) SCDHDAC3HDAC8NCOR2BRD4
SCHEMBL28427418 0.87 HDAC3 (0.33) SCDHDAC3HDAC8NCOR2BRD4
SCHEMBL23907203 0.87 AOC3 (0.38) AOC3MAOBKLKB1LMNAHPGD
SCHEMBL23907200 0.87 AOC3 (0.38) AOC3MAOBKLKB1LMNAHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111434662-B Haloallylamine compound and application thereof 药捷安康(南京)科技股份有限公司 2023-01-10 CN disclosed
CN-111434662-A Haloallylamine compound and application thereof 南京药捷安康生物科技有限公司 2020-07-21 CN disclosed