SCHEMBL28436573

SCHEMBL28436573

O=CC=Cc1c(O)cccc1F

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK4 P11802 2/20 0.50
CCND1 P24385 2/20 0.50
CCNB2 O95067 1/20 0.43
CDK1 P06493 1/20 0.43
CCNB1 P14635 1/20 0.43
CCNB3 Q8WWL7 1/20 0.43
MAOB P27338 2/20 0.42
ERN1 O75460 2/20 0.41
ABCG2 Q9UNQ0 1/20 0.41
XDH P47989 1/20 0.40
MAPT P10636 3/20 0.39
KDM4E B2RXH2 3/20 0.39
ALDH1A1 P00352 2/20 0.39
NFE2L2 Q16236 2/20 0.38
LMNA P02545 2/20 0.38
KMT2A Q03164 2/20 0.38
NPC1 O15118 1/20 0.38
HTT P42858 1/20 0.38
RAB9A P51151 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28436571 1.00 CDK4 (0.50) CDK4CCND1CCNB2CDK1CCNB1
SCHEMBL31074946 1.00 CDK4 (0.50) CDK4CCND1CCNB2CDK1CCNB1
SCHEMBL9159172 0.86 CDK4 (0.59) CDK4CCND1CCNB2CDK1CCNB1
SCHEMBL1399125 0.86 NFE2L2 (0.50) CDK4CCND1CCNB2CDK1CCNB1
SCHEMBL1399123 0.86 NFE2L2 (0.50) CDK4CCND1CCNB2CDK1CCNB1
SCHEMBL913980 0.79 ERN1 (0.52) MAOBERN1ABCG2MAPTKDM4E
SCHEMBL30989419 0.79 ERN1 (0.52) MAOBERN1ABCG2MAPTKDM4E
SCHEMBL15362056 0.77 SMN1; SMN2 (0.51) MAPTKDM4EALDH1A1LMNAKMT2A
SCHEMBL28431502 0.77 CDK4 (0.50) CDK4CCND1CCNB2CDK1CCNB1
SCHEMBL28870787 0.77 CDK4 (0.50) CDK4CCND1CCNB2CDK1CCNB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4665713-A1 NEMATICIDAL COMPOUNDS, THEIR COMPOSITION AND USE THEREOF Bhukhanwala, Komal (IN) 2025-12-24 EP disclosed
WO-2024171230-A1 NEMATICIDAL COMPOUNDS, THEIR COMPOSITION AND USE THEREOF BHUKHANWALA KOMAL (IN) 2024-08-22 WO disclosed
CN-111440190-B Preparation method of bacterial inhibitor coumarin [3,4] benzothiophene compound 诸暨市人民医院 2021-08-24 CN disclosed
CN-111440190-A Preparation method of bacterial inhibitor coumarin [3,4] benzothiophene compound 诸暨市人民医院 2020-07-24 CN disclosed