Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 12/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 12/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 10/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | TTR | P02766 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.37 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28437772 | 1.00 | PTGS1 (0.49) | PTGS1PTGS2ALOX5CYP3A4ALDH1A1 | |
| SCHEMBL28441995 | 0.85 | CYP3A4 (0.56) | CYP3A4ALDH1A1RECQLCYP2D6CYP17A1 | |
| SCHEMBL28441993 | 0.85 | CYP3A4 (0.56) | CYP3A4ALDH1A1RECQLCYP2D6CYP17A1 | |
| SCHEMBL13231546 | 0.81 | PTGS1 (0.53) | PTGS1PTGS2ALOX5CYP3A4ALDH1A1 | |
| SCHEMBL14984804 | 0.77 | ALDH1A1 (0.53) | PTGS1PTGS2ALOX5CYP3A4ALDH1A1 | |
| SCHEMBL17060490 | 0.77 | CA1 (0.82) | PTGS1PTGS2ALOX5CYP3A4ALDH1A1 | |
| SCHEMBL6484173 | 0.75 | ALDH1A1 (0.47) | PTGS1PTGS2ALOX5CYP3A4ALDH1A1 | |
| SCHEMBL6484162 | 0.75 | ALDH1A1 (0.47) | PTGS1PTGS2ALOX5CYP3A4ALDH1A1 | |
| SCHEMBL19116707 | 0.75 | CA1 (0.55) | PTGS1PTGS2ALOX5CYP3A4ALDH1A1 | |
| SCHEMBL6495364 | 0.75 | RXRB (0.47) | CYP3A4ALDH1A1RECQLCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111542515-B | TOLL-like receptor 8 (TLR 8) specific antagonists, methods of making and uses thereof | 科罗拉多州立大学董事会法人团体 | 2023-12-05 | — | — | CN | disclosed |
| CN-111542515-A | TOLL-like receptor 8(TLR8) specific antagonist and preparation method and application thereof | 科罗拉多州立大学董事会法人团体 | 2020-08-14 | — | — | CN | disclosed |