Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24405088 | 0.76 | ALDH1A1 (0.47) | KMT2AALDH1A1 | |
| SCHEMBL3674370 | 0.70 | HTT (0.41) | HTTSMN1; SMN2MAPTMAPK9ALDH1A1 | |
| SCHEMBL13727500 | 0.69 | HTT (0.48) | HTTPOLBSMN1; SMN2MAPTTSHR | |
| SCHEMBL2843864 | 0.68 | HTT (0.42) | HTTPOLBSMN1; SMN2KMT2AMAPT | |
| SCHEMBL27547450 | 0.66 | HTT (0.48) | HTTPOLBSMN1; SMN2MAPTTSHR | |
| SCHEMBL7001948 | 0.65 | HTT (0.44) | HTTPOLBSMN1; SMN2MAPTTSHR | |
| SCHEMBL7122892 | 0.65 | HTT (0.44) | HTTPOLBSMN1; SMN2MAPTTSHR | |
| SCHEMBL25478784 | 0.65 | ALDH1A1 (0.35) | KMT2AMAPTALDH1A1 | |
| SCHEMBL23269734 | 0.64 | HTT (0.51) | HTTPOLBSMN1; SMN2MAPTMAPK9 | |
| SCHEMBL14183799 | 0.63 | QDPR (0.54) | HTTPOLBSMN1; SMN2MAPTMAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010039911-A1 | CALCILYTIC COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-04-08 | — | — | WO | disclosed |