Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.57 |
| ▸ | FLT3 | P36888 | 2/20 | 0.57 |
| ▸ | SYK | P43405 | 10/20 | 0.56 |
| ▸ | STAT6 | P42226 | 5/20 | 0.53 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.52 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.52 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28441100 | 0.89 | JAK2 (0.61) | JAK2FLT3SYKSTAT6MAPK8 | |
| SCHEMBL28897515 | 0.86 | JAK3 (0.62) | JAK2FLT3SYKSTAT6 | |
| SCHEMBL24426171 | 0.84 | JAK2 (0.81) | JAK2FLT3SYK | |
| SCHEMBL28442021 | 0.83 | POLB (0.45) | STAT6MAPK8MAPK9MAPK10 | |
| SCHEMBL28437339 | 0.81 | JAK2 (0.75) | JAK2FLT3SYKMAPK8 | |
| SCHEMBL29669890 | 0.81 | JAK2 (0.75) | JAK2FLT3SYKMAPK8 | |
| SCHEMBL28442019 | 0.78 | — | — | |
| SCHEMBL1020619 | 0.78 | SYK (0.64) | SYK | |
| SCHEMBL28447910 | 0.75 | JAK3 (0.65) | JAK2SYKMAPK9MAPK10CSF1R | |
| SCHEMBL28434553 | 0.75 | MAPT (0.65) | JAK2FLT3SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111423384-B | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2021-10-15 | — | — | CN | claimed |
| CN-111423384-A | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2020-07-17 | — | — | CN | claimed |
| CN-111423384-B | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2021-10-15 | — | — | CN | disclosed |
| CN-111423384-A | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2020-07-17 | — | — | CN | disclosed |