Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.42 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14254704 | 0.87 | FPR2 (0.44) | HRH3SLC6A4SLC6A2SLC6A3OPRM1 | |
| Hydrochloric Acid SCHEMBL2084335 | 0.86 | SLC6A2 (0.51) | HRH3SLC6A4SLC6A2SLC6A3OPRM1 | |
| SCHEMBL11497550 | 0.85 | SLC6A2 (0.48) | HRH3SLC6A4SLC6A2SLC6A3OPRM1 | |
| SCHEMBL26694866 | 0.85 | OPRM1 (0.45) | HRH3SLC6A4SLC6A2SLC6A3OPRM1 | |
| SCHEMBL14665138 | 0.83 | SLC6A2 (0.53) | HRH3SLC6A4SLC6A2SLC6A3OPRM1 | |
| SCHEMBL11048760 | 0.82 | SLC6A2 (0.47) | HRH3SLC6A4SLC6A2SLC6A3KDM4E | |
| SCHEMBL14828670 | 0.81 | SLC6A2 (0.54) | HRH3SLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL11954278 | 0.81 | TACR1 (0.46) | HRH3SLC6A4SLC6A2SLC6A3OPRM1 | |
| SCHEMBL10956783 | 0.81 | SLC6A2 (0.56) | HRH3SLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL414249 | 0.81 | SLC6A2 (0.56) | HRH3SLC6A4SLC6A2SLC6A3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108864252-B | Method for preparing NRX-1074 | 中国人民解放军军事科学院军事医学研究院 | 2020-07-28 | — | — | CN | disclosed |