SCHEMBL28447451

SCHEMBL28447451

O=C(O)CCCc1cc(Br)ccc1[N+](=O)[O-]

nearest known ligand 0.47

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.47
FBP1 P09467 3/20 0.42
LMNA P02545 1/20 0.41
HPGD P15428 1/20 0.41
ATM Q13315 1/20 0.41
TDP1 Q9NUW8 3/20 0.40
MAPT P10636 3/20 0.40
MEN1 O00255 3/20 0.40
KMT2A Q03164 3/20 0.40
ALDH1A1 P00352 2/20 0.40
F13A1 P00488 3/20 0.39
KDM4E B2RXH2 1/20 0.39
GLA P06280 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.38
CASP6 P55212 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17807873 0.91 FBP1 (0.47) CYP1A2FBP1MAPTMEN1KMT2A
SCHEMBL30436271 0.83 ALDH1A1 (0.47) LMNAHPGDTDP1MAPTMEN1
SCHEMBL27289329 0.83 FBP1 (0.51) CYP1A2FBP1MAPTALDH1A1KDM4E
SCHEMBL4658271 0.82 ACLY (0.49) CYP1A2FBP1LMNAATMMAPT
SCHEMBL4658987 0.82 NPC1 (0.49) CYP1A2FBP1LMNATDP1MEN1
SCHEMBL30435068 0.82 ACLY (0.49) CYP1A2FBP1LMNAATMMAPT
SCHEMBL25410628 0.81 CYP1A2 (0.55) CYP1A2MAPTMEN1KMT2AKDM4E
SCHEMBL31232927 0.81 CYP1A2 (0.55) CYP1A2MAPTMEN1KMT2AKDM4E
SCHEMBL1352270 0.80 ALDH1A1 (0.53) CYP1A2LMNAHPGDATMTDP1
SCHEMBL4657892 0.80 ALDH1A1 (0.53) CYP1A2LMNAHPGDATMTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111479813-B Triazolobenzazepines as vasopressin V1A receptor antagonists 吉瑞工厂 2023-03-21 CN disclosed
CN-111479813-A Triazolobenzazepines as vasopressin V1A receptor antagonists 吉瑞工厂 2020-07-31 CN disclosed