Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10704844 | 0.82 | TRPM8 (0.41) | SMN1; SMN2HPGDLMNAALDH1A1MAPT | |
| SCHEMBL17735706 | 0.81 | ALDH1A1 (0.56) | MEN1KMT2ASMN1; SMN2HPGDLMNA | |
| SCHEMBL2578175 | 0.81 | SMN1; SMN2 (0.39) | MEN1KMT2AHSP90AA1SMN1; SMN2LMNA | |
| SCHEMBL10723987 | 0.81 | HDAC1 (0.41) | KMT2ASMN1; SMN2TDP1HPGDLMNA | |
| SCHEMBL11925050 | 0.79 | SMN1; SMN2 (0.43) | MEN1KMT2AHSP90AA1SMN1; SMN2TDP1 | |
| SCHEMBL14672264 | 0.79 | SMN1; SMN2 (0.45) | SMN1; SMN2LMNAALDH1A1CYP1A2MAPT | |
| SCHEMBL7980047 | 0.78 | ALDH1A1 (0.43) | MEN1KMT2AHSP90AA1SMN1; SMN2HPGD | |
| SCHEMBL2090069 | 0.76 | MEN1 (0.47) | MEN1KMT2AHSP90AA1TDP1HPGD | |
| SCHEMBL19707724 | 0.75 | ALDH1A1 (0.38) | MEN1KMT2ASMN1; SMN2HPGDLMNA | |
| SCHEMBL11774597 | 0.74 | MEN1 (0.44) | MEN1KMT2AHSP90AA1TDP1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111655681-B | Heterocyclylamino-substituted triazoles as modulators of Rho-related protein kinases | 莱德克斯制药公共有限公司 | 2024-01-05 | — | — | CN | disclosed |
| CN-111655681-A | Heterocyclylamino-substituted triazoles as modulators of Rho-associated protein kinase | 莱德克斯制药公共有限公司 | 2020-09-11 | — | — | CN | disclosed |