Acetoacetic Acid

Acetoacetic Acid

SCHEMBL28448993

C=CC(=C)C.CC(=O)CC(=O)O

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.50
TSHR P16473 5/20 0.50
TP53 P04637 1/20 0.50
ALOX15 P16050 1/20 0.48
HSD17B10 Q99714 1/20 0.48
KDM4E B2RXH2 2/20 0.41
KDM6B O15054 1/20 0.41
KDM5C P41229 1/20 0.41
EGLN1 Q9GZT9 1/20 0.41
PHF8 Q9UPP1 1/20 0.41
KDM2A Q9Y2K7 1/20 0.41
LDHA P00338 1/20 0.38
SRR Q9GZT4 1/20 0.38
LMNA P02545 2/20 0.36
SLC15A2 Q16348 1/20 0.36
MGAM O43451 1/20 0.35
GAA P10253 1/20 0.35
SI P14410 1/20 0.35
MGAM2 Q2M2H8 1/20 0.35
TDP1 Q9NUW8 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetoacetic Acid SCHEMBL1023325 0.87 ALOX15 (0.56) ALDH1A1TSHRTP53ALOX15HSD17B10
Acetoacetic Acid SCHEMBL7747946 0.87 ALOX15 (0.56) ALDH1A1TSHRTP53ALOX15HSD17B10
SCHEMBL8143281 0.87 ALDH1A1 (0.59) ALDH1A1TSHRTP53ALOX15HSD17B10
Acetoacetic Acid SCHEMBL29000066 0.85 ALOX15 (0.54) ALDH1A1TSHRTP53ALOX15HSD17B10
Acetoacetic Acid SCHEMBL23581266 0.84 KDM4E (0.44) ALDH1A1TSHRALOX15HSD17B10KDM4E
Acetoacetic Acid SCHEMBL30758649 0.84 KDM4E (0.44) ALDH1A1TSHRALOX15HSD17B10KDM4E
Acetoacetic Acid SCHEMBL1864033 0.84 KDM4E (0.44) ALDH1A1TSHRALOX15HSD17B10KDM4E
Acetoacetic Acid SCHEMBL27528835 0.83 TSHR (0.52) ALDH1A1TSHRALOX15HSD17B10KDM4E
Acetoacetic Acid SCHEMBL5797279 0.81 ALOX15 (0.50) ALDH1A1TSHRALOX15HSD17B10KDM4E
Acetoacetic Acid SCHEMBL10448884 0.81

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111587264-A Additive composition and application thereof 巴斯夫欧洲公司 2020-08-25 CN disclosed