Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | USP10 | Q14694 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28443100 | 0.87 | KDM4E (0.44) | EGFRKDM4ESMN1; SMN2MAPTKMT2A | |
| SCHEMBL28451603 | 0.85 | ALDH1A1 (0.43) | EGFRKDM4ESMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL28445463 | 0.85 | ALDH1A1 (0.43) | EGFRKDM4ESMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL28452127 | 0.84 | KMT2A (0.40) | EGFRKDM4ESMN1; SMN2MAPTKMT2A | |
| SCHEMBL28443055 | 0.76 | KDM4E (0.54) | KDM4ESMN1; SMN2MAPTKMT2AL3MBTL1 | |
| SCHEMBL28447306 | 0.76 | EGFR (0.46) | EGFRKDM4ESMN1; SMN2MAPTATM | |
| SCHEMBL28445478 | 0.76 | EGFR (0.46) | EGFRKDM4ESMN1; SMN2MAPTATM | |
| SCHEMBL28445422 | 0.75 | KDM4E (0.44) | EGFRKDM4EMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL28454187 | 0.75 | KDM4E (0.44) | EGFRKDM4EMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL28449263 | 0.74 | KDM4E (0.52) | KDM4EMAPTL3MBTL1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108997230-B | Quinoxaline derivative with matrix metalloproteinase inhibitory activity, preparation method and application thereof | 山东大学 | 2020-08-04 | — | — | CN | claimed |
| CN-108997230-B | Quinoxaline derivative with matrix metalloproteinase inhibitory activity, preparation method and application thereof | 山东大学 | 2020-08-04 | — | — | CN | disclosed |