Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | EEF2K | O00418 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5694237 | 0.80 | EP300 (0.34) | NOTUM | |
| SCHEMBL4727065 | 0.79 | NOTUM (0.30) | NOTUM | |
| SCHEMBL21186 | 0.67 | NOTUM (0.43) | NOTUM | |
| SCHEMBL5694084 | 0.67 | DNMT1 (0.37) | NOTUM | |
| SCHEMBL8228221 | 0.66 | ADORA2A (0.38) | SMN1; SMN2BRD4L3MBTL1 | |
| Methane SCHEMBL27916787 | 0.66 | NOTUM (0.42) | NOTUM | |
| SCHEMBL19310470 | 0.66 | GABRP (0.38) | BRD4L3MBTL1 | |
| SCHEMBL27696561 | 0.66 | EP300 (0.36) | — | |
| SCHEMBL27740855 | 0.64 | NOTUM (0.41) | NOTUM | |
| SCHEMBL19820712 | 0.63 | GABRP (0.52) | SMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111675660-B | Preparation method for synthesizing palbociclib intermediate and method for synthesizing palbociclib | 奥锐特药业股份有限公司 | 2021-12-10 | — | — | CN | disclosed |
| CN-111675660-A | Preparation method for synthesizing palbociclib intermediate and method for synthesizing palbociclib | 奥锐特药业股份有限公司 | 2020-09-18 | — | — | CN | disclosed |