Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ2 | O43526 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6421704 | 0.80 | ADORA1 (0.48) | KCNQ2ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL28898349 | 0.78 | HPGD (0.36) | KCNQ2HPGDALDH1A1RECQLNPSR1 | |
| SCHEMBL28457125 | 0.78 | ALDH1A1 (0.49) | HPGDALDH1A1NPSR1HTTSMN1; SMN2 | |
| SCHEMBL28446927 | 0.77 | HPGD (0.35) | KCNQ2HPGDALDH1A1RECQLNPSR1 | |
| SCHEMBL17815188 | 0.74 | KCNQ2 (0.40) | KCNQ2HPGDALDH1A1MAPTMEN1 | |
| SCHEMBL28796833 | 0.72 | HPGD (0.36) | HPGDALDH1A1RECQLNPSR1MAPT | |
| SCHEMBL28449514 | 0.70 | HDAC6 (0.32) | HPGDALDH1A1MAPT | |
| SCHEMBL30726807 | 0.69 | ALDH1A1 (0.51) | HPGDALDH1A1HTTSMN1; SMN2MAPT | |
| SCHEMBL29035272 | 0.69 | BPTF (0.41) | HPGDALDH1A1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL28901663 | 0.69 | MAPK1 (0.34) | HPGDALDH1A1RECQLNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107922430-B | 2-substituted benzimidazole-4-formamide compound and preparation method and application thereof | 中国科学院上海药物研究所 | 2020-09-04 | — | — | CN | disclosed |