SCHEMBL28449751

SCHEMBL28449751

C=C(C)C(=O)OC[SiH](CC)OCC

nearest known ligand 0.47

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
THRB P10828 1/20 0.47
TSHR P16473 4/20 0.42
ALDH1A1 P00352 4/20 0.37
POLB P06746 1/20 0.33
APEX1 P27695 1/20 0.33
HTT P42858 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
LMNA P02545 1/20 0.32
HSD17B10 Q99714 1/20 0.32
MGAM O43451 1/20 0.31
GAA P10253 1/20 0.31
SI P14410 1/20 0.31
MGAM2 Q2M2H8 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2581746 0.81 THRB (0.50) THRBTSHRALDH1A1POLBAPEX1
SCHEMBL2568266 0.80 TSHR (0.53) THRBTSHRALDH1A1POLBAPEX1
SCHEMBL8955366 0.76 THRB (0.46) THRBTSHRALDH1A1POLBAPEX1
SCHEMBL5164067 0.75 TSHR (0.56) THRBTSHRALDH1A1POLBAPEX1
SCHEMBL339022 0.73 TSHR (0.58) THRBTSHRALDH1A1POLBAPEX1
SCHEMBL340973 0.73 TSHR (0.62) THRBTSHRALDH1A1POLBAPEX1
SCHEMBL16537818 0.73 THRB (0.55) THRBTSHRALDH1A1POLBAPEX1
SCHEMBL19409375 0.73 THRB (0.64) THRBTSHRALDH1A1LMNAHSD17B10
SCHEMBL15030 0.73
SCHEMBL17059985 0.71 TSHR (0.50) THRBTSHRALDH1A1POLBAPEX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111465659-B Coating composition for sealing surfaces 瓦克化学股份公司 2022-09-27 CN disclosed
CN-111465659-A Coating composition for sealing surfaces 瓦克化学股份公司 2020-07-28 CN disclosed