SCHEMBL28450613

SCHEMBL28450613

C[Si](C)(C)C#CCOc1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 2/20 0.50
GRM5 P41594 7/20 0.43
KCNA3 P22001 1/20 0.41
EGFR P00533 1/20 0.41
LTA4H P09960 1/20 0.39
CA12 O43570 1/20 0.39
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39
CA7 P43166 1/20 0.39
CA9 Q16790 1/20 0.39
LMNA P02545 1/20 0.38
HTR1D P28221 1/20 0.38
HTR1B P28222 1/20 0.38
TAAR1 Q96RJ0 1/20 0.38
ALDH1A1 P00352 1/20 0.38
RECQL P46063 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9306983 0.83 KCNH2 (0.46) KCNH2GRM5KCNA3EGFRLTA4H
SCHEMBL9306972 0.83 KCNH2 (0.46) KCNH2GRM5KCNA3EGFRLTA4H
SCHEMBL8349909 0.82 GRM5 (0.54) GRM5CA12CA1CA2CA7
SCHEMBL9808291 0.80 KCNH2 (0.57) KCNH2KCNA3EGFRLTA4HCA12
SCHEMBL9338770 0.77 KCNH2 (0.55) KCNH2KCNA3LTA4HCA12CA1
SCHEMBL6265267 0.77 KCNH2 (0.55) KCNH2KCNA3LTA4HCA12CA1
SCHEMBL1790840 0.76 KCNH2 (0.53) KCNH2KCNA3EGFRLTA4HCA12
SCHEMBL811636 0.75 KCNH2 (0.43) KCNH2GRM5KCNA3EGFRLTA4H
SCHEMBL14085300 0.75 KCNH2 (0.53) KCNH2KCNA3LTA4HCA12CA1
Diphenylether SCHEMBL10632533 0.74 LTA4H (0.57) KCNH2KCNA3LTA4HCA12CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107459438-B Novel practical nonmetal-catalyzed silica-based deprotection method 台州学院 2020-09-01 CN disclosed