Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.66 |
| ▸ | ITK | Q08881 | 8/20 | 0.66 |
| ▸ | BTK | Q06187 | 5/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
| ▸ | JAK3 | P52333 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24900775 | 0.84 | BTK (0.69) | EGFRITKBTKJAK2JAK3 | |
| SCHEMBL28445845 | 0.84 | EGFR (0.60) | EGFRITKBTK | |
| SCHEMBL28444667 | 0.83 | SYK (0.59) | EGFRITK | |
| SCHEMBL29722518 | 0.79 | EGFR (1.00) | EGFRITKBTKJAK2JAK3 | |
| SCHEMBL12519706 | 0.79 | EGFR (1.00) | EGFRITKBTKJAK2JAK3 | |
| SCHEMBL12518349 | 0.79 | EGFR (0.81) | EGFRITKBTK | |
| SCHEMBL28059266 | 0.78 | EGFR (0.77) | EGFRITKBTK | |
| SCHEMBL28059334 | 0.78 | BTK (0.85) | EGFRITKBTKJAK2JAK3 | |
| SCHEMBL13498206 | 0.76 | EGFR (0.81) | EGFRITKBTK | |
| SCHEMBL17071724 | 0.76 | BTK (0.63) | EGFRBTKJAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105384694-B | Substituted aminopyrimidine derivative and preparation method and pharmaceutical application thereof | 四川海思科制药有限公司 | 2020-09-04 | — | — | CN | disclosed |