Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 2/20 | 0.49 |
| ▸ | IDO1 | P14902 | 4/20 | 0.42 |
| ▸ | KDM1A | O60341 | 3/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | ATR | Q13535 | 2/20 | 0.39 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.38 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21274528 | 0.76 | CD274 (0.43) | — | |
| SCHEMBL28132401 | 0.75 | HTR2B (0.47) | HTR2BIDO1KDM1ATRIM24TRIM33 | |
| SCHEMBL29518695 | 0.74 | IDO1 (0.43) | HTR2BIDO1KDM1AALOX5APFEN1 | |
| SCHEMBL22402524 | 0.74 | HTR2B (0.54) | HTR2BIDO1TRIM24TRIM33ERN1 | |
| SCHEMBL2643887 | 0.73 | FEN1 (0.66) | IDO1KDM1AALOX5APFEN1 | |
| SCHEMBL1825784 | 0.69 | KCNJ1 (0.48) | ALDH1A1 | |
| Iodide SCHEMBL28714110 | 0.67 | KCNJ1 (0.47) | ALDH1A1 | |
| SCHEMBL11886380 | 0.67 | IDO1 (0.47) | IDO1KDM1AALOX5APFEN1CYP19A1 | |
| SCHEMBL31681935 | 0.67 | IDO1 (0.47) | IDO1KDM1AALOX5APFEN1CYP19A1 | |
| SCHEMBL14988372 | 0.67 | CCR6 (0.48) | KDM1AALDH1A1HPGDRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112047891-B | Synthesis method and application of 2-hydroxyphenyl-5-pyrazinyl ketone | 合肥工业大学 | 2021-11-30 | — | — | CN | claimed |
| CN-112047891-B | Synthesis method and application of 2-hydroxyphenyl-5-pyrazinyl ketone | 合肥工业大学 | 2021-11-30 | — | — | CN | disclosed |
| CN-112047891-A | Synthesis method and application of 2-hydroxyphenyl-5-pyrazinyl ketone | 合肥工业大学 | 2020-12-08 | — | — | CN | disclosed |
| CN-111662236-A | Synthesis method and application of 2-hydroxyphenyl-5-pyrazinyl ketone | 合肥工业大学 | 2020-09-15 | — | — | CN | disclosed |