Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11973525 | 0.87 | RAB9A (0.53) | TDP1RAB9AALDH1A1POLBCYP2C9 | |
| SCHEMBL11973532 | 0.87 | RAB9A (0.53) | TDP1RAB9AALDH1A1POLBCYP2C9 | |
| SCHEMBL168448 | 0.86 | RAB9A (0.47) | TDP1TSHRRAB9AALDH1A1POLB | |
| SCHEMBL168447 | 0.86 | RAB9A (0.47) | TDP1TSHRRAB9AALDH1A1POLB | |
| SCHEMBL14965456 | 0.82 | MEN1 (0.49) | TDP1TSHRSMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL14965454 | 0.82 | MEN1 (0.49) | TDP1TSHRSMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL3842471 | 0.80 | TDP1 (0.58) | TDP1TSHRSMN1; SMN2ALDH1A1POLB | |
| SCHEMBL29124763 | 0.80 | GPR35 (0.57) | TDP1TSHRRAB9AALDH1A1POLB | |
| SCHEMBL28613448 | 0.79 | MEN1 (0.42) | TDP1TSHRRAB9AALDH1A1POLB | |
| SCHEMBL23421580 | 0.79 | TDP1 (0.56) | TDP1TSHRSMN1; SMN2RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111683927-A | Modulators of indoleamine 2, 3-dioxygenase | 葛兰素史克知识产权开发有限公司 | 2020-09-18 | — | — | CN | disclosed |