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SCHEMBL28460725

SCHEMBL28460725

CN(C(=O)c1cc(Br)nn1-c1ncccc1Cl)c1c(Cl)cc(Cl)cc1C(=O)NC(C)(C)C

nearest known ligand 0.53

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ DHODH Q02127 3/20 0.38
▸ CNR1 P21554 2/20 0.33
▸ CNR2 P34972 2/20 0.33
▸ SMN1; SMN2 Q16637 1/20 0.32
▸ TRPV1 Q8NER1 3/20 0.32
▸ TRPA1 O75762 2/20 0.32
▸ KCNH2 Q12809 1/20 0.32
▸ TRPM8 Q7Z2W7 1/20 0.32
▸ ALDH1A1 P00352 1/20 0.32
▸ TSHR P16473 1/20 0.32
▸ ABCB1 P08183 1/20 0.32
▸ ALPL P05186 1/20 0.32
▸ PSD A5PKW4 1/20 0.31
▸ DGAT2 Q96PD7 1/20 0.31
▸ ANO1 Q5XXA6 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24397959 0.90 DHODH (0.39) DHODHTRPV1
SCHEMBL28451020 0.88 DHODH (0.38) DHODHCNR1CNR2SMN1; SMN2KCNH2
SCHEMBL24397793 0.88 CHIA (0.39) DHODHCNR1CNR2SMN1; SMN2ALDH1A1
SCHEMBL24397797 0.87 DHODH (0.37) DHODHCNR1CNR2TRPA1ALDH1A1
SCHEMBL29181560 0.87 DHODH (0.37) DHODHCNR1SMN1; SMN2TRPA1
SCHEMBL29181519 0.87 DHODH (0.37) DHODHCNR2TRPV1TRPA1
SCHEMBL29129837 0.87 DHODH (0.36) DHODHSMN1; SMN2TRPA1ALDH1A1
SCHEMBL28451730 0.86 DHODH (0.37) DHODH
SCHEMBL28455067 0.86 POLB (0.39) DHODHCNR1CNR2SMN1; SMN2
SCHEMBL28451477 0.86 MEN1 (0.39) DHODHCNR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117285508-A Preparation method of pyridyl pyrazole amide compound and intermediate thereof 湖南化工研究院有限公司 2023-12-26 — — CN claimed
CN-117263908-A Preparation of 1-pyridylpyrazole amide compound and intermediate thereof 湖南化工研究院有限公司 2023-12-22 — — CN claimed
CN-116264894-A Preparation and application of 1-pyridylpyrazole amide compound 湖南化工研究院有限公司 2023-06-20 — — CN claimed
CN-114516855-A Preparation of pyridylpyrazole amide compounds and intermediates therefor 湖南化工研究院有限公司 2022-05-20 — — CN claimed
CN-114516854-A Preparation method of 1-pyridyl pyrazole amide compound and intermediate thereof 湖南化工研究院有限公司 2022-05-20 — — CN claimed
CN-111662269-B 1-pyridyl pyrazole amide compound and preparation method and application thereof 湖南化工研究院有限公司 2021-05-07 — — CN claimed
CN-111662269-A 1-pyridyl pyrazole amide compound and preparation method and application thereof 湖南化工研究院有限公司 2020-09-15 — — CN claimed
CN-116264894-B Preparation and application of 1-pyridylpyrazole amide compound 湖南化工研究院有限公司 2024-07-09 — — CN disclosed
CN-117285508-A Preparation method of pyridyl pyrazole amide compound and intermediate thereof 湖南化工研究院有限公司 2023-12-26 — — CN disclosed
CN-117263908-A Preparation of 1-pyridylpyrazole amide compound and intermediate thereof 湖南化工研究院有限公司 2023-12-22 — — CN disclosed
CN-116264894-A Preparation and application of 1-pyridylpyrazole amide compound 湖南化工研究院有限公司 2023-06-20 — — CN disclosed
CN-114516855-A Preparation of pyridylpyrazole amide compounds and intermediates therefor 湖南化工研究院有限公司 2022-05-20 — — CN disclosed
CN-114516854-A Preparation method of 1-pyridyl pyrazole amide compound and intermediate thereof 湖南化工研究院有限公司 2022-05-20 — — CN disclosed
CN-111662269-B 1-pyridyl pyrazole amide compound and preparation method and application thereof 湖南化工研究院有限公司 2021-05-07 — — CN disclosed
CN-111662269-A 1-pyridyl pyrazole amide compound and preparation method and application thereof 湖南化工研究院有限公司 2020-09-15 — — CN disclosed
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