Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.45 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5572445 | 0.78 | — | — | |
| Fumaric Acid SCHEMBL27171220 | 0.75 | TSHR (0.60) | TSHRTP53EGLN1EGLN3MEN1 | |
| SCHEMBL9188910 | 0.74 | KDM4E (0.30) | MEN1KMT2A | |
| Methane SCHEMBL7920519 | 0.74 | — | — | |
| SCHEMBL9730109 | 0.74 | KDM4E (0.30) | MEN1KMT2A | |
| SCHEMBL8554549 | 0.74 | — | — | |
| Fumaric Acid SCHEMBL793772 | 0.71 | TSHR (0.90) | TSHRTP53EGLN1EGLN3MEN1 | |
| Fumaric Acid SCHEMBL363366 | 0.71 | TSHR (0.90) | TSHRTP53EGLN1EGLN3MEN1 | |
| Fumaric Acid SCHEMBL21815645 | 0.71 | — | — | |
| Maleic Acid SCHEMBL7337222 | 0.71 | TSHR (0.90) | TSHRTP53EGLN1EGLN3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108912179-B | Application of mononuclear nickel complex containing mnt ligand as electrocatalytic hydrogen production catalyst | 四川理工学院 | 2020-06-23 | — | — | CN | disclosed |