Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OGG1 | O15527 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4979894 | 0.83 | LMNA (0.53) | ALDH1A1HPGDKDM4EKMT2ANPC1 | |
| SCHEMBL12301897 | 0.83 | LMNA (0.53) | ALDH1A1HPGDKDM4EKMT2ANPC1 | |
| SCHEMBL24227433 | 0.83 | PRMT5 (0.57) | ALDH1A1HPGDKDM4EKMT2APRMT5 | |
| SCHEMBL9781002 | 0.83 | PRMT5 (0.52) | ALDH1A1HPGDKDM4EPRMT5NPC1 | |
| SCHEMBL13157814 | 0.83 | LMNA (0.53) | ALDH1A1HPGDKDM4EKMT2ANPC1 | |
| SCHEMBL31226138 | 0.83 | KDM4E (0.48) | ALDH1A1HPGDKDM4EKMT2APRMT5 | |
| SCHEMBL6154030 | 0.82 | NPC1 (0.64) | ALDH1A1HPGDKDM4EKMT2APRMT5 | |
| SCHEMBL3465056 | 0.82 | NPC1 (0.64) | ALDH1A1HPGDKDM4EKMT2APRMT5 | |
| SCHEMBL16898615 | 0.81 | OGG1 (0.63) | OGG1ALDH1A1HPGDOPRM1OPRD1 | |
| SCHEMBL21590151 | 0.81 | ALDH1A1 (0.56) | OGG1ALDH1A1HPGDKDM4EOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111788195-B | Protein kinase MKK4 inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death | 海帕瑞吉尼克斯股份有限公司 | 2023-11-21 | — | — | CN | disclosed |
| CN-111788195-A | Protein kinase MKK4 inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death | 海帕瑞吉尼克斯股份有限公司 | 2020-10-16 | — | — | CN | disclosed |