Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | FBP1 | P09467 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | GALR2 | O43603 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28899829 | 0.89 | FBP1 (0.42) | POLBVCAM1THRBALDH1A1LMNA | |
| SCHEMBL28455680 | 0.87 | ALDH1A1 (0.45) | POLBVCAM1THRBALDH1A1LMNA | |
| SCHEMBL1653079 | 0.78 | ALDH1A1 (0.41) | POLBALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL1655587 | 0.76 | MAPT (0.40) | POLBALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL28461394 | 0.76 | CYP4F2 (0.42) | POLBALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL28459988 | 0.75 | FBP1 (0.72) | MAPTKMT2AMEN1FBP1HPGD | |
| SCHEMBL703225 | 0.73 | ALDH1A1 (0.50) | POLBALDH1A1LMNAMAPTPKM | |
| SCHEMBL6303401 | 0.73 | CCR2 (0.74) | POLBALDH1A1LMNAMAPTMAPK1 | |
| SCHEMBL4653080 | 0.72 | F10 (0.45) | POLBALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL7665395 | 0.71 | FBP1 (0.53) | POLBVCAM1THRBALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107098846-B | N-acyl sulfonamide FBPase inhibitor, preparation method thereof, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2020-10-09 | — | — | CN | disclosed |