Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | LDHA | P00338 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 6/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.48 |
| ▸ | WNT3A | P56704 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.47 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.46 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2840775 | 0.84 | HPGDS (0.46) | HPGDSTP53NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2840773 | 0.83 | HPGDS (0.45) | HPGDSTP53NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2412802 | 0.83 | LMNA (0.53) | HPGDSSMN1; SMN2MAPTHIF1A | |
| SCHEMBL6027765 | 0.82 | HPGDS (0.44) | HPGDSTP53NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL17261484 | 0.82 | EPHX2 (0.49) | HPGDSTP53NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL17273999 | 0.82 | CKS1B (0.50) | HPGDSTP53NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL17261555 | 0.82 | ALDH1A1 (0.50) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2843167 | 0.81 | HPGDS (0.55) | HPGDSNPC1RAB9ASMN1; SMN2HIF1A | |
| SCHEMBL23828889 | 0.81 | HCAR2 (0.55) | TP53NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL6027764 | 0.81 | HPGDS (0.43) | HPGDSTP53NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015172196-A1 | HETEROCYCLIC COMPOUNDS AND USE OF SAME | MONASH UNIVERSITY (AU) | 2015-11-19 | — | — | WO | disclosed |
| EP-2251324-A1 | HETEROARYL-ALKYLCARBAMATE COMPOUNDS AND THEIR USE AS INHIBITORS OF THE FAAH ENZYME | Sanofi-Aventis (FR) | 2010-11-17 | — | — | EP | disclosed |
| EP-1720829-B1 | DERIVATIVES OF HETEROARYL-ALKYLCARBAMATES, PREPARATION METHOD THEREOF AND USE OF SAME AS FAAH ENZYME INHIBITORS | SANOFI AVENTIS (FR) | 2009-10-14 | — | — | EP | disclosed |
| EP-1720829-A1 | DERIVATIVES OF HETEROARYL-ALKYLCARBAMATES, PREPARATION METHOD THEREOF AND USE OF SAME AS FAAH ENZYME INHIBITORS | Sanofi-Aventis (FR) | 2006-11-15 | — | — | EP | disclosed |
| WO-2005090292-A1 | DERIVATIVES OF HETEROARYL-ALKYLCARBAMATES, PREPARATION METHOD THEREOF AND USE OF SAME AS FAAH ENZYME INHIBITORS | SANOFI-AVENTIS (FR) | 2005-09-29 | — | — | WO | disclosed |