Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 6/20 | 0.50 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LDHA | P00338 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL19350210 | 1.00 | CA4 (0.50) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL27890522 | 0.95 | CA4 (0.46) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL14861914 | 0.95 | CA4 (0.58) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL27148837 | 0.95 | CA4 (0.55) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL5493709 | 0.95 | CA4 (0.55) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL4807761 | 0.95 | CA4 (0.55) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL8218022 | 0.95 | CA4 (0.42) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL222993 | 0.95 | CA4 (0.55) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL5655343 | 0.91 | CA4 (0.54) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL27695617 | 0.91 | CA4 (0.54) | CA4FAHD1CA1MEN1LDHA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4013739-B1 | NEW TELESCOPING SYNTHESES OF 2-METHOXYMETHYL-P-PHENYLENEDIAMINE | WELLA GERMANY GMBH (DE) | 2024-10-02 | — | — | EP | claimed |
| US-20220298101-A1 | NEW TELESCOPING SYNTHESES OF 2-METHOXYMETHYL-P-PHENYLENEDIAMINE | WELLA GERMANY GMBH (DE) | 2022-09-22 | — | — | US | claimed |
| EP-4013739-A1 | NEW TELESCOPING SYNTHESES OF 2-METHOXYMETHYL-P-PHENYLENEDIAMINE | Wella Germany GmbH (DE) | 2022-06-22 | — | — | EP | claimed |
| WO-2021028506-A1 | NEW TELESCOPING SYNTHESES OF 2-METHOXYMETHYL-P-PHENYLENEDIAMINE | COTY INC. (US) | 2021-02-18 | — | — | WO | claimed |
| CN-109746999-A | A kind of wood fire retardant | 丹阳市博元安全生产服务有限公司 | 2019-05-14 | — | — | CN | claimed |
| CN-104924390-A | Wood fire retardant | ZHANG PING | 2015-09-23 | — | — | CN | claimed |
| CN-104478267-A | Calcium carbonate and sodium carbonate complexing agent and preparation method thereof | YIXING TIANLI CHEMICAL NANO TECHNOLOGY CO LTD | 2015-04-01 | — | — | CN | claimed |
| CN-104478268-A | Calcium carbonate and sodium bicarbonate complexing agent and preparation method thereof | YIXING TIANLI CHEMICAL NANO TECHNOLOGY CO LTD | 2015-04-01 | — | — | CN | claimed |
| EP-0918559-A1 | PAINT FOR NONHAZARDOUS REMOVAL OF HEAVY METALS AND METHOD FOR USING THE SAME | RMT, Inc. (US) | 1999-06-02 | — | — | EP | claimed |
| WO-1998000202-A1 | PAINT FOR NONHAZARDOUS REMOVAL OF HEAVY METALS AND METHOD FOR USING THE SAME | RMT, INC. (US) | 1998-01-08 | — | — | WO | claimed |
| US-20240417971-A1 | VAPOR PERMEABLE, WATER RESISTIVE, AND FIRE RESISTIVE ARTICLES | HEXION INC. | 2024-12-19 | — | — | US | disclosed |
| WO-2024258614-A2 | POLE CAPS AND POLE PROTECTION SYSTEMS | HEXION INC. (US) | 2024-12-19 | — | — | WO | disclosed |
| WO-2024258616-A2 | VAPOR PERMEABLE, WATER RESISTIVE, AND FIRE RESISTIVE ARTICLES | HEXION INC. (US) | 2024-12-19 | — | — | WO | disclosed |
| US-20240417993-A1 | POLE CAPS AND POLE PROTECTION SYSTEMS | HEXION INC. | 2024-12-19 | — | — | US | disclosed |
| US-20240139480-A1 | RETENTIVE DEVICES FOR GASTROINTESTINAL TRACT | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2024-05-02 | — | — | US | disclosed |
| US-5068235-A | For treatment of senile dementia | TAIHO PHARMACEUTICAL COMPANY, LIMITED (JP) | 1991-11-26 | — | — | US | disclosed |
| US-4690776-A | Method of manufacture of a toothpaste composition | ROBELL RESEARCH, INC. | 1987-09-01 | — | — | US | disclosed |
| US-4603045-A | Toothpaste for bonded (composite filling material) as well as natural teeth | ROBELL RESEARCH, INC. | 1986-07-29 | — | — | US | disclosed |
| US-4440779-A | Tricyclic derivatives of substituted pyrrole acids as analgesic and anti-inflammatory agents | MERCK & CO., INC. (US) | 1984-04-03 | — | — | US | disclosed |
| EP-0068460-A1 | Tricyclic derivatives of substituted pyrrole acids as analgesic and anti-inflammatory agents | MERCK & CO. INC. (US) | 1983-01-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220298101-A1 | NEW TELESCOPING SYNTHESES OF 2-METHOXYMETHYL-P-PHENYLENEDIAMINE | PNMT, TYR, DDT | CA4 3454/4885FAHD1 3895/4885CA1 4858/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.