Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 6/20 | 0.55 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LDHA | P00338 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL222993 | 1.00 | CA4 (0.55) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL8009950 | 0.95 | CA4 (0.50) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL8421151 | 0.95 | CA4 (0.50) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL9013971 | 0.95 | CA4 (0.50) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL7983250 | 0.95 | CA4 (0.50) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL10525004 | 0.95 | CA4 (0.50) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL10379498 | 0.95 | CA4 (0.50) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL15103409 | 0.95 | CA4 (0.50) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL15666483 | 0.95 | CA4 (0.50) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL7996596 | 0.95 | CA4 (0.50) | CA4FAHD1CA1MEN1LDHA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080274052-A1 | RADIOFLORINATION METHODS | GE HEALTHCARE LIMITED (GB) | 2008-11-06 | — | — | US | disclosed |
| US-7368474-B2 | Radiofluorination methods | GE HEALTHCARE LIMITED (GB) | 2008-05-06 | — | — | US | disclosed |
| EP-1335020-B1 | POLYPEPTIDES HAVING ALPHA-ISOMALTOSYL TRANSFERASE ACTIVITY | HAYASHIBARA BIOCHEM LAB (JP) | 2007-06-13 | — | — | EP | disclosed |
| US-7098013-B2 | Polypeptide having α-isomaltosyl-transferase activity | KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) | 2006-08-29 | — | — | US | disclosed |
| US-20050142061-A1 | Radiofluorination methods | GE HEALTHCARE LIMITED (GB) | 2005-06-30 | — | — | US | disclosed |
| US-20040121431-A1 | used for formation of cyclotetrasaccharide from a saccharide with a glucose polymerization degree of 3 or higher; genetic engineering | KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) | 2004-06-24 | — | — | US | disclosed |
| EP-1335020-A1 | POLYPEPTIDES HAVING ALPHA-ISOMALTOSYL TRANSFERASE ACTIVITY | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo (JP) | 2003-08-13 | — | — | EP | disclosed |
| EP-0481436-B1 | Integral multilayer analytical element for determination of ammonia or ammonia-producing substance | FUJI PHOTO FILM CO LTD (JP) | 1997-01-29 | — | — | EP | disclosed |
| US-5286624-A | Indicator layer contains polyvinyl alkyl ether as binder polymer | FUJI PHOTO FILM CO., LTD. (JP) | 1994-02-15 | — | — | US | disclosed |
| US-5196518-A | Dizonium slat coupled with hydroxy compound | CIBA-GEIGY CORPORATION (US) | 1993-03-23 | — | — | US | disclosed |
| EP-0481436-A1 | Integral multilayer analytical element for determination of ammonia or ammonia-producing substance | FUJI PHOTO FILM CO., LTD. (JP) | 1992-04-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050142061-A1 | Radiofluorination methods | SSTR4, VIP, SSTR5 | CA4 292/4885FAHD1 1670/4885CA1 426/4885 |
| US-20040121431-A1 | used for formation of cyclotetrasaccharide from a saccharide with a glucose polymerization degree of 3 or higher; genetic engineering | UGGT1, IDUA, GALE | CA4 1849/4885FAHD1 1677/4885CA1 2836/4885 |
| US-20080274052-A1 | RADIOFLORINATION METHODS | VIP, QRFPR, SSTR4 | CA4 2019/4885FAHD1 910/4885CA1 1722/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.