Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG known ✓ | P37231 | 6/20 | 0.54 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | FAAH | O00519 | 1/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.54 |
| ▸ | PPARD | Q03181 | 6/20 | 0.54 |
| ▸ | PPARA | Q07869 | 6/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.54 |
| ▸ | TSHR | P16473 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | TLR2 | O60603 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | FABP4 | P15090 | 2/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL29516769 | 1.00 | SOAT1 (0.64) | SOAT1MEN1KMT2AFAAHTP53 | |
| Maleic Acid SCHEMBL30619142 | 1.00 | SOAT1 (0.64) | SOAT1MEN1KMT2AFAAHTP53 | |
| Maleic Acid SCHEMBL30415773 | 1.00 | SOAT1 (0.64) | SOAT1MEN1KMT2AFAAHTP53 | |
| Maleic Acid SCHEMBL27347708 | 0.98 | SOAT1 (0.61) | SOAT1MEN1KMT2AFAAHTP53 | |
| Maleic Acid SCHEMBL3281709 | 0.91 | SOAT1 (0.82) | SOAT1MEN1KMT2AFAAHTP53 | |
| Oleamide SCHEMBL3280975 | 0.91 | SOAT1 (0.82) | SOAT1MEN1KMT2AFAAHTP53 | |
| Nonane SCHEMBL8674797 | 0.89 | HCAR2 (0.59) | CYP1A2TDP1 | |
| Nonane SCHEMBL8674791 | 0.89 | HCAR2 (0.59) | CYP1A2TDP1 | |
| Octadecanoic Acid Amide SCHEMBL31304701 | 0.88 | SOAT1 (0.56) | SOAT1MEN1KMT2AFAAHTP53 | |
| Octadecanoic Acid Amide SCHEMBL28235692 | 0.86 | MEN1 (0.68) | SOAT1MEN1KMT2AFAAHTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106978157-B | Linear gel fracturing fluid for reservoir automatic gel breaking and preparation method thereof | 西南石油大学 | 2020-09-29 | — | — | CN | disclosed |