Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 9/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30880761 | 0.92 | LMNA (0.52) | NAMPTSMN1; SMN2LMNAMEN1ALDH1A1 | |
| SCHEMBL30880731 | 0.92 | NAMPT (0.50) | NAMPTSMN1; SMN2LMNAMEN1ALDH1A1 | |
| SCHEMBL8234022 | 0.81 | LMNA (0.62) | SMN1; SMN2LMNAKDM4ECYP1A2CYP2C9 | |
| SCHEMBL30880764 | 0.80 | POLB (0.59) | SMN1; SMN2LMNAMEN1ALDH1A1KMT2A | |
| SCHEMBL21722478 | 0.80 | POLB (0.59) | SMN1; SMN2LMNAMEN1ALDH1A1KMT2A | |
| SCHEMBL21722438 | 0.77 | SMYD3 (0.55) | NAMPTSMN1; SMN2LMNAKMT2AKDM4E | |
| SCHEMBL30880779 | 0.76 | POLB (0.69) | NAMPTSMN1; SMN2LMNAMEN1ALDH1A1 | |
| SCHEMBL3461687 | 0.76 | NAMPT (0.49) | NAMPTSMN1; SMN2LMNAMEN1ALDH1A1 | |
| SCHEMBL3463033 | 0.76 | NAMPT (0.49) | NAMPTSMN1; SMN2LMNAMEN1ALDH1A1 | |
| SCHEMBL29519760 | 0.76 | NAMPT (0.51) | NAMPTSMN1; SMN2LMNAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115181092-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2024-05-03 | — | — | CN | disclosed |
| CN-115181092-A | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-10-14 | — | — | CN | disclosed |
| CN-112279837-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-08-09 | — | — | CN | disclosed |
| CN-111747954-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2021-08-24 | — | — | CN | disclosed |
| CN-112279837-A | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2021-01-29 | — | — | CN | disclosed |
| CN-112055709-A | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2020-12-08 | — | — | CN | disclosed |
| CN-111747954-A | Pyrazine compounds and uses thereof | 迪哲（江苏）医药有限公司 | 2020-10-09 | — | — | CN | disclosed |