Cloperastine

Cloperastine

SCHEMBL284715

Clc1ccc(C(OCCN2CCCCC2)c2ccccc2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 3/20 1.00
SLC6A4 P31645 3/20 1.00
SLC6A3 Q01959 3/20 1.00
CYP3A4 P08684 2/20 1.00
CYP1A2 P05177 2/20 1.00
CYP2D6 P10635 2/20 1.00
TSHR P16473 2/20 1.00
CYP2C19 P33261 2/20 1.00
HIF1A Q16665 2/20 1.00
SLC22A1 O15245 1/20 1.00
CHRM2 P08172 1/20 1.00
HTR1A P08908 1/20 1.00
ADRA2A P08913 1/20 1.00
CHRM1 P11229 1/20 1.00
DRD1 P21728 1/20 1.00
TBXA2R P21731 1/20 1.00
ADRA1A P35348 1/20 1.00
OPRM1 P35372 1/20 1.00
DRD3 P35462 1/20 1.00
KCNH2 Q12809 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Cloperastine SCHEMBL9613613 1.00 SLC6A2 (1.00) SLC6A2SLC6A4SLC6A3CYP3A4CYP1A2
Cloperastine SCHEMBL29617329 1.00 SLC6A2 (1.00) SLC6A2SLC6A4SLC6A3CYP3A4CYP1A2
Cloperastine SCHEMBL23733 0.99 CYP3A4 (1.00) SLC6A2SLC6A4SLC6A3CYP3A4CYP1A2
SCHEMBL1151981 0.99 SLC6A2 (0.97) SLC6A2SLC6A4SLC6A3CYP3A4CYP1A2
Cloperastine SCHEMBL1651228 0.97 SLC6A2 (0.95) SLC6A2SLC6A4SLC6A3CYP3A4CYP1A2
Perastine SCHEMBL1506306 0.91 CYP3A4 (0.83) SLC6A2SLC6A4SLC6A3CYP3A4CYP1A2
Perastine SCHEMBL29768269 0.90 CYP3A4 (0.83) SLC6A2SLC6A4SLC6A3CYP3A4CYP1A2
SCHEMBL9050633 0.86 SIGMAR1 (0.84) SLC6A2SLC6A4SLC6A3CYP3A4CYP1A2
Difencloxazine SCHEMBL29710921 0.86 SLC6A2 (0.76) SLC6A2SLC6A4SLC6A3CYP3A4CYP1A2
SCHEMBL17942915 0.86 CYP3A4 (0.75) SLC6A2SLC6A4SLC6A3CYP3A4CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2145 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12550885-B2 Red blood cell storage solutions, solution additives, and methods for improving the storage of red blood cells UNIVERSITY OF CINCINNATI (US) 2026-02-17 US claimed
EP-4658278-A1 SELECTIVE FIASMA TREATMENT Valo Health, Inc. (US) 2025-12-10 EP claimed
EP-4609859-A1 INHIBITORS OF THE GENE SMPD1 FOR THE TREATMENT OF SPINAL MUSCULAR ATROPHY Universidad Pablo de Olavide (ES) 2025-09-03 EP claimed
US-20250255781-A1 PROCESSES FOR PREPARATION OF 3-D PRINTED PHARMACEUTICAL PRODUCTS BRISTOL-MYERS SQUIBB COMPANY (US) 2025-08-14 US claimed
WO-2025111482-A1 COMPLEXING AGENT SALT FORMULATIONS OF PHARMACEUTICAL COMPOUNDS AT LOW STOICHIOMETRIC RATIOS BEXSON BIOMEDICAL, INC. (US) 2025-05-30 WO claimed
US-12296043-B2 Liquisoft capsules PATHEON SOFTGELS INC. (US) 2025-05-13 US claimed
EP-4510999-A1 PROCESSES FOR PREPARATION OF 3-D PRINTED PHARMACEUTICAL PRODUCTS Bristol-Myers Squibb Company (US) 2025-02-26 EP claimed
US-20240373748-A1 Organic Compound, Light-Emitting Device, Light-Emitting Apparatus, Electronic Device, and Lighting Device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2024-11-07 US claimed
WO-2024163699-A1 SELECTIVE FIASMA TREATMENT VALO HEALTH, INC. (US) 2024-08-08 WO claimed
US-20240226084-A9 HIGH PENETRATION PRODRUG COMPOSITIONS AND PHARMACEUTICAL COMPOSITION THEREOF FOR TREATMENT OF PULMONARY CONDITIONS TECHFIELDS PHARMA CO., LTD. (CN) 2024-07-11 US claimed
EP-1226831-A1 Aqueous pharmaceutical solutions with trisubstituted glycyrrhizic acid salts Baiocchi, Leandro (IT) 2002-07-31 EP claimed
WO-2002055530-A2 TRANSCOBALAMIN BINDING CONJUGATES USEFUL FOR TREATING ABNORMAL CELLULAR PROLIFERATION MAYO FOUNDATION (US) 2002-07-18 WO claimed
EP-1073470-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2001-02-07 EP claimed
WO-2000048636-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2000-08-24 WO claimed
EP-0664118-B1 SUSTAINED-RELEASE TABLET YOSHITOMI PHARMACEUTICAL (JP) 1999-08-25 EP claimed
CN-1043302-C Group of drugs with antitussive and expectorant functions ZHANG JUNYE (CN) 1999-05-12 CN claimed
EP-0894794-A1 Optical isomers of cloperastine AESCULAPIUS FARMACEUTICI S.r.l. (IT) 1999-02-03 EP claimed
EP-0582380-B1 Dry granulation using a fluidized bed MCNEIL PPC INC (US) 1996-09-04 EP claimed
CN-1102567-A Group of drugs with antitussive and expectorant functions ZHANG JUNYE (CN) 1995-05-17 CN claimed
EP-0385491-A1 Optically active isomer of cloperastine possessing antitussive activity, a process for its preparation and pharmaceutical compositions which contain it MAGIS FARMACEUTICI S.p.A. (IT) 1990-09-05 EP claimed