Cloperastine

Cloperastine

SCHEMBL29617329

Clc1ccc([C@@H](OCCN2CCCCC2)c2ccccc2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 3/20 1.00
SLC6A4 P31645 3/20 1.00
SLC6A3 Q01959 3/20 1.00
CYP3A4 P08684 2/20 1.00
CYP1A2 P05177 2/20 1.00
CYP2D6 P10635 2/20 1.00
TSHR P16473 2/20 1.00
CYP2C19 P33261 2/20 1.00
HIF1A Q16665 2/20 1.00
SLC22A1 O15245 1/20 1.00
CHRM2 P08172 1/20 1.00
HTR1A P08908 1/20 1.00
ADRA2A P08913 1/20 1.00
CHRM1 P11229 1/20 1.00
DRD1 P21728 1/20 1.00
TBXA2R P21731 1/20 1.00
ADRA1A P35348 1/20 1.00
OPRM1 P35372 1/20 1.00
DRD3 P35462 1/20 1.00
KCNH2 Q12809 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Cloperastine SCHEMBL9613613 1.00 SLC6A2 (1.00) SLC6A2SLC6A4SLC6A3CYP3A4CYP1A2
Cloperastine SCHEMBL284715 1.00 SLC6A2 (1.00) SLC6A2SLC6A4SLC6A3CYP3A4CYP1A2
Cloperastine SCHEMBL23733 0.99 CYP3A4 (1.00) SLC6A2SLC6A4SLC6A3CYP3A4CYP1A2
SCHEMBL1151981 0.99 SLC6A2 (0.97) SLC6A2SLC6A4SLC6A3CYP3A4CYP1A2
Cloperastine SCHEMBL1651228 0.97 SLC6A2 (0.95) SLC6A2SLC6A4SLC6A3CYP3A4CYP1A2
Perastine SCHEMBL1506306 0.91 CYP3A4 (0.83) SLC6A2SLC6A4SLC6A3CYP3A4CYP1A2
Perastine SCHEMBL29768269 0.90 CYP3A4 (0.83) SLC6A2SLC6A4SLC6A3CYP3A4CYP1A2
SCHEMBL9050633 0.86 SIGMAR1 (0.84) SLC6A2SLC6A4SLC6A3CYP3A4CYP1A2
Difencloxazine SCHEMBL29710921 0.86 SLC6A2 (0.76) SLC6A2SLC6A4SLC6A3CYP3A4CYP1A2
SCHEMBL17942915 0.86 CYP3A4 (0.75) SLC6A2SLC6A4SLC6A3CYP3A4CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3644968-B1 LEVOCLOPERASTINE FENDIZOATE SUSPENSION HAVING ENHANCED DISSOLUTION AND RESUSPENDABILITY ILKO ILAC SANAYI VE TICARET ANONIM SIRKETI (TR) 2025-01-08 EP claimed
US-20230390271-A1 ANTI-VERTIGO COMPOUND AND PHARMACEUTICAL COMPOSITIONS THEREOF AMNEAL PHARMACEUTICALS LLC 2023-12-07 US claimed
EP-4736841-A1 A MUCOADHESIVE LAYER FOR BUCCAL ADMINISTRATION OF AN ACTIVE PHARMACEUTICAL INGREDIENT IQ medical GmbH (DE) 2026-05-06 EP disclosed
EP-3644968-B1 LEVOCLOPERASTINE FENDIZOATE SUSPENSION HAVING ENHANCED DISSOLUTION AND RESUSPENDABILITY ILKO ILAC SANAYI VE TICARET ANONIM SIRKETI (TR) 2025-01-08 EP disclosed
EP-3644968-B1 LEVOCLOPERASTINE FENDIZOATE SUSPENSION HAVING ENHANCED DISSOLUTION AND RESUSPENDABILITY ILKO ILAC SANAYI VE TICARET ANONIM SIRKETI (TR) 2025-01-08 EP disclosed
EP-4299059-A1 COMPOSITION FOR THE TREATMENT OF TINNITUS Labelic Analysis, S.L. (ES) 2024-01-03 EP disclosed
US-20230390271-A1 ANTI-VERTIGO COMPOUND AND PHARMACEUTICAL COMPOSITIONS THEREOF AMNEAL PHARMACEUTICALS LLC 2023-12-07 US disclosed
US-20230390271-A1 ANTI-VERTIGO COMPOUND AND PHARMACEUTICAL COMPOSITIONS THEREOF AMNEAL PHARMACEUTICALS LLC 2023-12-07 US disclosed
WO-2022091118-A1 ANTI-VERTIGO COMPOUND AND PHARMACEUTICAL COMPOSITIONS THEREOF AMERISE PHARMACEUTICALS PVT LTD. (IN) 2022-05-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230390271-A1 ANTI-VERTIGO COMPOUND AND PHARMACEUTICAL COMPOSITIONS THEREOF VDAC3, HRH2, VDAC2 SLC6A2 629/4885SLC6A4 936/4885SLC6A3 1050/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.