Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 14/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.45 |
| ▸ | WNK1 | Q9H4A3 | 2/20 | 0.44 |
| ▸ | BCL2 | P10415 | 1/20 | 0.43 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1700079 | 0.91 | MAPT (0.48) | ALDH1A1WNK1BCL2BCL2L1 | |
| SCHEMBL4445873 | 0.90 | GPR119 (0.54) | GPR119ALDH1A1 | |
| SCHEMBL16657351 | 0.85 | MAPT (0.47) | GPR119ALDH1A1 | |
| SCHEMBL2252021 | 0.85 | USP30 (0.45) | ALDH1A1WNK1 | |
| SCHEMBL16485883 | 0.85 | LMNA (0.48) | ALDH1A1 | |
| SCHEMBL13543525 | 0.84 | GPR119 (0.64) | GPR119 | |
| SCHEMBL3609601 | 0.84 | GPR119 (0.64) | GPR119 | |
| SCHEMBL28475966 | 0.84 | GPR119 (0.49) | GPR119 | |
| SCHEMBL1700253 | 0.83 | MAPT (0.50) | GPR119ALDH1A1ALDH3A1WNK1BCL2 | |
| SCHEMBL2483201 | 0.83 | MAPT (0.50) | GPR119ALDH1A1ALDH3A1WNK1BCL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111704613-B | Imidazole derivatives and their use as TRPV4 inhibitors | 中国人民解放军军事科学院军事医学研究院 | 2021-07-06 | — | — | CN | disclosed |
| CN-111704613-A | Imidazole derivatives and their use as TRPV4 inhibitors | 中国人民解放军军事科学院军事医学研究院 | 2020-09-25 | — | — | CN | disclosed |