Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 7/20 | 0.48 |
| ▸ | HTR2C | P28335 | 5/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | P4HA1 | P13674 | 2/20 | 0.39 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.39 |
| ▸ | MIF | P14174 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20177003 | 0.82 | HTR2C (0.42) | HTR2CSLC6A4HDAC1HDAC8HDAC6 | |
| SCHEMBL29686229 | 0.82 | HTR2C (0.42) | HTR2CSLC6A4HDAC1HDAC8HDAC6 | |
| SCHEMBL6018000 | 0.80 | HDAC3 (0.43) | HCAR3MAPTL3MBTL1HDAC1HDAC3 | |
| SCHEMBL31132955 | 0.80 | HTR2C (0.46) | HTR2CSLC6A4MAPTHTR2A | |
| SCHEMBL691501 | 0.79 | HCAR3 (0.51) | HCAR3MAPTL3MBTL1P4HA1P4HTM | |
| SCHEMBL18109829 | 0.79 | HTR2C (0.43) | HTR2CSLC6A4 | |
| SCHEMBL1243793 | 0.79 | HDAC1 (0.46) | HTR2CSLC6A4MAPTHDAC1HDAC6 | |
| SCHEMBL30662236 | 0.78 | RORC (0.42) | HTR2CSLC6A4HDAC1HDAC8HDAC6 | |
| SCHEMBL1713633 | 0.78 | HCAR3 (0.55) | HCAR3MAPTP4HA1P4HTMMIF | |
| SCHEMBL1770925 | 0.77 | HCAR3 (0.50) | HCAR3MAPTL3MBTL1P4HA1P4HTM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100130471-A1 | Renin Inhibitors | SMITHKLINE BEECHAM CORPORATION | 2010-05-27 | — | — | US | disclosed |
| US-20100130471-A1 | Renin Inhibitors | SMITHKLINE BEECHAM CORPORATION | 2010-05-27 | — | — | US | disclosed |
| WO-2008124582-A1 | RENIN INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-10-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130471-A1 | Renin Inhibitors | ACE, REN, DNPEP | HCAR3 2871/4885HTR2C 4087/4885SLC6A4 1461/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.