Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 2/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21138339 | 0.89 | BTK (0.51) | BTKGPR119PIK3CDADORA1JAK1 | |
| SCHEMBL21138181 | 0.89 | BTK (0.51) | BTKGPR119PIK3CDADORA1JAK1 | |
| SCHEMBL21138782 | 0.89 | BTK (0.51) | BTKGPR119PIK3CDADORA1JAK1 | |
| SCHEMBL10137689 | 0.89 | GPR119 (0.56) | BTKGPR119PIK3CDPOLBADORA1 | |
| SCHEMBL3343756 | 0.81 | EHMT2 (0.39) | BTKGPR119POLBCNR1CNR2 | |
| SCHEMBL15145741 | 0.79 | BTK (0.58) | BTKGPR119PIK3CDADORA1CNR1 | |
| SCHEMBL23409113 | 0.78 | BTK (0.44) | BTKGPR119PIK3CDADORA1JAK1 | |
| SCHEMBL5930702 | 0.78 | PIK3CD (0.51) | BTKGPR119PIK3CDADORA1CNR1 | |
| SCHEMBL5930705 | 0.78 | PIK3CD (0.51) | BTKGPR119PIK3CDADORA1CNR1 | |
| SCHEMBL31626228 | 0.77 | BTK (0.47) | BTKGPR119PIK3CDADORA1CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111704613-B | Imidazole derivatives and their use as TRPV4 inhibitors | 中国人民解放军军事科学院军事医学研究院 | 2021-07-06 | — | — | CN | disclosed |
| CN-111704613-A | Imidazole derivatives and their use as TRPV4 inhibitors | 中国人民解放军军事科学院军事医学研究院 | 2020-09-25 | — | — | CN | disclosed |