Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 2/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.36 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28474913 | 0.81 | BTK (0.46) | EHMT2BTKCNR1CNR2USP30 | |
| SCHEMBL3700678 | 0.76 | ALDH1A1 (0.52) | EHMT2BTKCNR1CNR2GPR119 | |
| SCHEMBL4572401 | 0.76 | ALDH1A1 (0.50) | EHMT2BTKCNR1CNR2USP30 | |
| SCHEMBL23090042 | 0.75 | MEN1 (0.44) | EHMT2BTKPIM1PIM2CNR1 | |
| SCHEMBL29736622 | 0.75 | MEN1 (0.44) | EHMT2BTKPIM1PIM2CNR1 | |
| SCHEMBL16826782 | 0.75 | BTK (0.41) | EHMT2BTKUSP30POLBNPC1 | |
| SCHEMBL3403790 | 0.75 | PIK3CA (0.43) | BTK | |
| SCHEMBL17196811 | 0.73 | STK17B (0.48) | EHMT2BTKPIM1PIM2CNR1 | |
| SCHEMBL30841705 | 0.73 | ALDH1A1 (0.49) | EHMT2BTKPIM1PIM2CNR1 | |
| SCHEMBL3775852 | 0.72 | HSP90AA1 (0.47) | EHMT2PIM1PIM2POLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379555-B1 | PURINE COMPOUNDS | LILLY CO ELI (US) | 2015-02-25 | — | — | EP | disclosed |
| EP-2379555-B1 | PURINE COMPOUNDS | LILLY CO ELI (US) | 2015-02-25 | — | — | EP | disclosed |
| US-8252798-B2 | Purine compounds | ELI LILLY AND COMPANY (US) | 2012-08-28 | — | — | US | disclosed |
| US-8252798-B2 | Purine compounds | ELI LILLY AND COMPANY (US) | 2012-08-28 | — | — | US | disclosed |
| US-8252798-B2 | Purine compounds | ELI LILLY AND COMPANY (US) | 2012-08-28 | — | — | US | disclosed |
| WO-2010080306-A1 | PURINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2010-07-15 | — | — | WO | disclosed |
| US-20100160288-A1 | Purine Compounds | ELI LILLY AND COMPANY | 2010-06-24 | — | — | US | disclosed |
| US-20100160288-A1 | Purine Compounds | ELI LILLY AND COMPANY | 2010-06-24 | — | — | US | disclosed |
| US-20100160288-A1 | Purine Compounds | ELI LILLY AND COMPANY | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160288-A1 | Purine Compounds | P2RX1, P2RX7, P2RX5 | EHMT2 4553/4885BTK 3918/4885PIM1 4135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.