Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | APP | P05067 | 3/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | DBH | P09172 | 1/20 | 0.47 |
| ▸ | SNCA | P37840 | 2/20 | 0.46 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.46 |
| ▸ | GCGR | P47871 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ADCYAP1R1 | P41586 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6192299 | 0.87 | ALDH1A1 (0.51) | HTR6ALDH1A1LMNASMN1; SMN2TDP1 | |
| SCHEMBL8394619 | 0.87 | APP (0.63) | HTR6ALDH1A1LMNASMN1; SMN2TDP1 | |
| SCHEMBL8687683 | 0.84 | ALDH1A1 (0.56) | HTR6ALDH1A1LMNASMN1; SMN2TDP1 | |
| SCHEMBL28239179 | 0.84 | ALDH1A1 (0.51) | HTR6ALDH1A1LMNASMN1; SMN2TDP1 | |
| SCHEMBL8685326 | 0.84 | ALDH1A1 (0.72) | HTR6ALDH1A1LMNASMN1; SMN2TDP1 | |
| SCHEMBL4361317 | 0.84 | ALDH1A1 (0.72) | ALDH1A1LMNASMN1; SMN2TDP1PARP1 | |
| SCHEMBL30487285 | 0.84 | ALDH1A1 (0.72) | ALDH1A1LMNASMN1; SMN2TDP1PARP1 | |
| SCHEMBL8685733 | 0.83 | ALDH1A1 (0.53) | HTR6ALDH1A1LMNASMN1; SMN2TDP1 | |
| SCHEMBL8685406 | 0.81 | APP (0.49) | HTR6ALDH1A1LMNASMN1; SMN2TDP1 | |
| SCHEMBL8685269 | 0.81 | SMN1; SMN2 (0.50) | HTR6ALDH1A1LMNASMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108047226-B | Matrine pyrrole and indole derivatives, and preparation method and application thereof | 广西大学 | 2020-11-03 | — | — | CN | claimed |
| CN-108047226-A | Matrine pyrroles, indole derivatives and preparation method and application | 广西大学 | 2018-05-18 | — | — | CN | disclosed |