Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | KIF18A | Q8NI77 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.31 |
| ▸ | BACE1 | P56817 | 2/20 | 0.30 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28474245 | 0.86 | NNMT (0.45) | NNMTGSK3B | |
| SCHEMBL28473395 | 0.72 | NNMT (0.42) | NNMTGSK3BBACE1 | |
| Hydracarbazine SCHEMBL308554 | 0.70 | NNMT (0.55) | NNMTGSK3B | |
| SCHEMBL4889620 | 0.69 | HCAR3 (0.46) | NNMT | |
| SCHEMBL3174330 | 0.69 | NNMT (0.67) | NNMTGSK3B | |
| SCHEMBL7667785 | 0.68 | NNMT (0.49) | NNMTGSK3B | |
| SCHEMBL28479050 | 0.68 | GSK3B (0.50) | NNMTGSK3B | |
| SCHEMBL31211632 | 0.67 | NNMT (0.47) | NNMTGSK3B | |
| SCHEMBL30542994 | 0.67 | NNMT (0.44) | NNMTGSK3BKIF18AGABRA1CNR2 | |
| SCHEMBL28477862 | 0.65 | GSK3B (0.44) | NNMTGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115448910-A | Pyridazine derivative inhibitor, and preparation method and application thereof | 江苏豪森药业集团有限公司 | 2022-12-09 | — | — | CN | disclosed |
| CN-111757878-A | Pyridazine derivative inhibitor, and preparation method and application thereof | 江苏豪森药业集团有限公司 | 2020-10-09 | — | — | CN | disclosed |