Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 2/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 2/20 | 0.32 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.31 |
| ▸ | GLS | O94925 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.30 |
| ▸ | FPR2 | P25090 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28479219 | 0.86 | NNMT (0.41) | NNMTGSK3B | |
| SCHEMBL28473395 | 0.78 | NNMT (0.42) | NNMTGSK3BGLS | |
| Hydracarbazine SCHEMBL308554 | 0.73 | NNMT (0.55) | NNMTGSK3BPIM1SIRT6 | |
| SCHEMBL4889620 | 0.72 | HCAR3 (0.46) | NNMTPIM1 | |
| SCHEMBL3174330 | 0.72 | NNMT (0.67) | NNMTGSK3BPIM1SIRT6 | |
| SCHEMBL7667785 | 0.71 | NNMT (0.49) | NNMTGSK3B | |
| SCHEMBL31211632 | 0.70 | NNMT (0.47) | NNMTGSK3BGLS | |
| SCHEMBL28476212 | 0.69 | DGAT1 (0.42) | NNMTGSK3BGLS | |
| SCHEMBL28477862 | 0.68 | GSK3B (0.44) | NNMTGSK3BGLS | |
| SCHEMBL5042245 | 0.68 | HCAR3 (0.48) | NNMTGSK3BSCN9AFPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117263918-A | Pyridazine derivative inhibitor, preparation method and application thereof | 江苏豪森药业集团有限公司 | 2023-12-22 | — | — | CN | disclosed |
| CN-111757878-B | Pyridazine derivative inhibitor, preparation method and application thereof | 江苏豪森药业集团有限公司 | 2023-07-28 | — | — | CN | disclosed |
| CN-115448910-A | Pyridazine derivative inhibitor, and preparation method and application thereof | 江苏豪森药业集团有限公司 | 2022-12-09 | — | — | CN | disclosed |
| CN-111757878-A | Pyridazine derivative inhibitor, and preparation method and application thereof | 江苏豪森药业集团有限公司 | 2020-10-09 | — | — | CN | disclosed |