Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.38 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.36 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28476786 | 0.92 | KMT2A (0.40) | JAK2JAK1TYK2JAK3KDM1A | |
| SCHEMBL28570368 | 0.88 | JAK2 (0.43) | JAK2JAK1TYK2JAK3KDM1A | |
| SCHEMBL30421230 | 0.88 | JAK2 (0.43) | JAK2JAK1TYK2JAK3KDM1A | |
| SCHEMBL29062245 | 0.86 | JAK2 (0.44) | JAK2JAK1TYK2JAK3KDM1A | |
| SCHEMBL28851424 | 0.86 | JAK2 (0.44) | JAK2JAK1TYK2JAK3KDM1A | |
| SCHEMBL6942857 | 0.86 | JAK2 (0.44) | JAK2JAK1TYK2JAK3KDM1A | |
| SCHEMBL29013151 | 0.84 | MEN1 (0.37) | EPHX2DRD2MAPTKMT2ADRD3 | |
| SCHEMBL28604392 | 0.81 | EPHX2 (0.38) | KDM1AMAOBEPHX2CTSLCTSB | |
| SCHEMBL28587573 | 0.80 | EPHX2 (0.37) | JAK2JAK1KDM1AMAOBEPHX2 | |
| SCHEMBL28704162 | 0.78 | PTGDR2 (0.42) | DRD2KMT2AL3MBTL1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112778183-B | Nitrogen-containing ring derivative regulator, preparation method and application thereof | 江苏豪森药业集团有限公司 | 2024-05-10 | — | — | CN | disclosed |
| CN-111770754-B | Polycyclic derivative regulator, preparation method and application thereof | 江苏豪森药业集团有限公司 | 2023-09-19 | — | — | CN | disclosed |
| CN-113166135-A | Benzothiophene derivative modulators, methods of making, and uses thereof | 上海翰森生物医药科技有限公司 | 2021-07-23 | — | — | CN | disclosed |
| CN-112778183-A | Nitrogen-containing ring derivative regulator, preparation method and application thereof | 江苏豪森药业集团有限公司 | 2021-05-11 | — | — | CN | disclosed |
| CN-111770754-A | Polycyclic derivative regulator, preparation method and application thereof | 江苏豪森药业集团有限公司 | 2020-10-13 | — | — | CN | disclosed |