Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28479502 | 0.84 | JAK2 (0.41) | KMT2AEPHX2MAPTDRD2DRD3 | |
| SCHEMBL28476786 | 0.81 | KMT2A (0.40) | KMT2AEPHX2LMNANPSR1MAPT | |
| SCHEMBL9076971 | 0.78 | EPHX2 (0.41) | MEN1KMT2AEPHX2LMNANPSR1 | |
| SCHEMBL28704162 | 0.77 | PTGDR2 (0.42) | MEN1KMT2ADRD2DRD4DRD3 | |
| SCHEMBL29260227 | 0.75 | EPHX2 (0.45) | EPHX2LMNA | |
| SCHEMBL26672156 | 0.74 | PTGDR2 (0.39) | KMT2AEPHX2LMNANPSR1 | |
| SCHEMBL29013154 | 0.74 | GPR119 (0.43) | MEN1RAB9AKMT2AGPR119MMP13 | |
| SCHEMBL30981046 | 0.73 | MMP13 (0.44) | MEN1RAB9AKMT2ALMNAGPR119 | |
| SCHEMBL28421464 | 0.73 | CYP1A2 (0.48) | MEN1KMT2ALMNANPSR1MAPT | |
| SCHEMBL3918082 | 0.73 | ALDH1A1 (0.38) | MEN1KMT2AEPHX2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116261458-B | PLK1 degradation inducing compounds | 厄普特拉株式会社 | 2024-05-24 | — | — | CN | disclosed |
| CN-117794936-A | Novel PLK1 degradation inducing compounds | 厄普特拉株式会社 | 2024-03-29 | — | — | CN | disclosed |
| CN-116322700-A | Novel PLK1 degradation inducing compounds | 厄普特拉株式会社 | 2023-06-23 | — | — | CN | disclosed |
| CN-116261458-A | Novel PLK1 degradation inducing compounds | 厄普特拉株式会社 | 2023-06-13 | — | — | CN | disclosed |