Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.42 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.41 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28851424 | 1.00 | JAK2 (0.44) | JAK2JAK1TYK2JAK3KDM1A | |
| SCHEMBL6942857 | 1.00 | JAK2 (0.44) | JAK2JAK1TYK2JAK3KDM1A | |
| SCHEMBL29172685 | 0.91 | KMT2A (0.41) | JAK2JAK1TYK2JAK3KDM1A | |
| SCHEMBL28570368 | 0.89 | JAK2 (0.43) | JAK2JAK1TYK2JAK3KDM1A | |
| SCHEMBL30421230 | 0.89 | JAK2 (0.43) | JAK2JAK1TYK2JAK3KDM1A | |
| SCHEMBL28479502 | 0.86 | JAK2 (0.41) | JAK2JAK1TYK2JAK3KDM1A | |
| SCHEMBL28397690 | 0.84 | EPHX2 (0.44) | EPHX2KMT2AMAPTL3MBTL1 | |
| SCHEMBL6942861 | 0.81 | JAK2 (0.44) | JAK2JAK1TYK2JAK3KDM1A | |
| SCHEMBL9101971 | 0.81 | PTGDR2 (0.39) | EPHX2DRD2KMT2AMAPTL3MBTL1 | |
| SCHEMBL2217850 | 0.77 | PTGDR2 (0.46) | EPHX2KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116675731-A | Small molecule conjugate of targeted cyclin-dependent kinase 12/13 and application thereof | 浙江大学 | 2023-09-01 | — | — | CN | disclosed |